【摘要】 目的 探讨胃癌及癌前病变组织中p53基因蛋白的表达及意义。方法 应用免疫组织化学染色方法对74例慢性胃炎，59例肠上皮化生，66例异型增生和81例胃癌进行了p53基因蛋白检测。结果 正常胃粘膜与慢性胃炎中无p53表达，随着异型增生程度的增加，p53阳性表达也在增加，重度异型增生的阳性率与胃癌的阳性率相近。结论 p53蛋白在胃癌前病变中即显示异常表达，其突变发生于胃粘膜癌变的早期阶段，p53蛋白的表达对于鉴别胃良恶性病变具有较大意义。

    关键词 胃癌 癌前病变 p53蛋白

    The expression and significance of p53protein in gastric carcinoma and precancerous lesions Ding Hongji，Li Aiying，Li Xingong，et al.

    Department of pathology，Sheng Li Petroleum Administration Central Hospital，Dongying257034.

    【Abstract】 Objective To study the expression and significance of p53protein In gastric carcinoma and precanˉcerous lesions.Methods The expressions of p53protein were detected by immunohitochemical method in74chronic gasˉtritis，59intestinal metaplasia，66dysplasia and81gastric carcinomas.Results There were no expression of p53in the normal gastric membrane and chronic gastritis.The positive rate of p53was increasing with increment of degree of dysplaˉsia.The positive rate of severe dysplasia was similar to gastric carcinoma.Conclusion The mutati ......