【摘要】 目的 探讨老年脑梗塞与幽门螺杆菌细胞毒素相关蛋白A(Cag-A)的关系。方法 应用酶联免疫法(ELISA)检测65例老年脑梗塞患者和50例对照组血清幽门螺杆菌细胞毒素相关蛋白A IgG抗体(CagA-Hp-IgG)以及血清总胆固醇(TC)，甘油三酯(TG)，载脂蛋白A(Apo-A)、载脂蛋白B(Apo-B)、高密度脂蛋白胆固醇(HDL-C)，低密度脂蛋白胆固醇(LDL-C)浓度。结果 老年脑梗塞组血清CagA-Hp-IgG阳性率(53.85%)显著高于对照组(34%)(P<0.05)。CagA-HP-IgG阳性与阴性者间血脂水平比较差异无显著性(P>0.05)。结论 老年脑梗塞的发病与Hp感染尤其是Cag-A阳性Hp菌株感染有关，其可能的发病机制不明。

    关键词 幽门螺杆菌 幽门螺杆菌细胞毒素相关蛋白A 感染 脑梗塞

    Study of the relationship between cerebral infarction in elderly patients

    and helicobacter pylori bearing the cytotoxin associated gene A

    Huang Zhiyong，Wu Xiuxin，Huang Donghong

    Department of Neurology，the People’s Hospital of Huizhou，Huizhou516002.

    【Abstract】 Objective To explore the relationship between cerebral infarction in elderly patients and Heliˉcobacter Pylori bearing the cytotoxinassociated gene.Methods Serum cytotoxin-associated gene A IgG antibodies to HP(CagA-Hp-IgG)(enzyme linked immunosorbent assay)and serum concentrations of total cholesterol(TC) ......