胃癌腹膜转移研究之策略
戴冬秋,中国医科大学附属第一医院肿瘤科、辽宁省胃癌分子病理重点实验室 辽宁省沈阳市 110001
戴冬秋,男, 1963-10-04生, 辽宁省凤城市人,蒙古族,中国医科大学医学博士,教授, 主任医师,博士生导师.2000-2002年美国M.D.安德森癌症中心博士后研究员,中国抗癌协会全国胃癌专业委员会委员,《CMJ》及《世界华人消化杂志》等5刊编委及审稿人.主要从事肿瘤外科,化疗及生物治疗等工作,专于胃癌转移分子机制及早期预测与阻断的基础和临床研究.
国家自然科学基金项目,No. 30271477
教育部留学回国人员科研启动基金项目,No. 2002-247
辽宁省自然科学基金项目,No. 972273, No. 001037
, 百拇医药
通讯作者:戴冬秋, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属第一医院肿瘤科、辽宁省胃癌分子病理重点实验室.daidq63@163.com
电话:024-23256666-6227
收稿日期:2005-03-01 接受日期: 2005-03-11
摘要
腹膜复发转移是胃癌根治术后复发的主要形式，成为影响胃癌疗效的关键问题.胃癌腹膜播散转移的形成是一个多因素参与、多阶段的复杂病理生理过程，其中，腹膜亚临床转移的早期预测与及时阻断尤为重要.本文评述了胃癌腹膜转移机制、早诊、预防及治疗的研究进展和策略，着重分析了进展期胃癌根治术后腹膜亚临床转移早期预测方法及预防措施的地位与存在问题.
, http://www.100md.com
关键词:胃癌;腹膜转移; 预测;治疗
戴冬秋.胃癌腹膜转移研究之策略.世界华人消化杂志 2005;13(9):1049-10511 Maehara Y, Hasuda S, Koga T, Tokunaga E, Kakeji Y, Sugimachi K.Postoperative outcome and sites of recurrence in
patients following curative resection ofgastric cancer. Br J Surg 2000;87:353-357
2 Kiyasu Y, Kaneshima S, Koga S. Morphogenesis of peritonealmetastasis in human gastric cancer.
, http://www.100md.com
Cancer Res 1981;41:1236-1239
3 Hagiwara A, Takahashi T, Sawai K, Taniguchi H, Shimotsuma M, OkanoS, Sakakura C, Tsujimoto H, Osaki K,Sasaki S. Milky spots as the implantationsite for malignant cells in peritoneal dissemination in mice.
Cancer Res 1993;53:687-692
4 戴冬秋, 陈峻青, 徐蕾, 赵凤凯, 吴东瑛. 胃癌组织中E-钙黏附素表达的定量检测及临床病理学评价.
中华医学杂志 1997;77:668-671
, http://www.100md.com
5 戴冬秋, 陈峻青, 徐惠绵, 王舒宝, 赵凤凯, 王梅先. E-钙黏附素及a-链接素的表达与胃癌生物学行为及
淋巴结转移规律的关系. 中华肿瘤杂志 2001;23:35-38
6 杨军, 戴冬秋. 胃癌原发灶与转移灶E-钙黏附素mRNA表达水平的比较研究. 中华肿瘤杂志 2005;27:25-28
7 Matsuoka T, Yashiro M, Nishimura S, Inoue T, Fujihara T, Sawada T,Kato Y, Seki S, Hirakawa-Ys Chung K.
Increased expression ofalpha2beta1-integrin in the peritoneal dissemination of human gastriccarcinoma.
, http://www.100md.com
Int J Mol Med 2000;5:21-25
8 Nishimura S, Chung YS, Yashiro M, Inoue T, Sowa M. CD44H plays animportant role in peritoneal dissemination
of scirrhous gastric cancer cells. Jpn JCancer Res 1996;87:1235-1244
9 戴冬秋, 陈峻青, 赵凤凯, 吴东瑛, 王梅先. 细胞黏附分子CD44S、CD44V6在胃癌组织中的表达及其意义.
中华肿瘤杂志 1998;20:376-379
10 徐惠绵, 王剑峰, 王振宁. CEA mRNA、CEA蛋白及细胞学检测胃癌腹腔液中游离癌细胞的初步评价.
, http://www.100md.com
中华肿瘤杂志 2000;22:45-47
11 戴冬秋, 陈峻青, 任常山, 张文范. b-葡萄糖醛酸酶对胃癌诊断及分型意义的研究.
中华肿瘤杂志 1992;14:316-317
12 Yonemura Y, Endou Y, Fujita H, Fushida S, Bandou E, Taniguchi K,Miwa K, Sugiyama K, Sasaki T. Role of MMP-7 in
the formation of peritonealdissemination in gastric cancer. Gastric Cancer 2000;3:63-70
13 Fondevila C, Metges JP, Fuster J, Grau JJ, Palacin A, Gastells A, Volant A, Pera M. p53 and VEGFexpression
, 百拇医药
are independent predictors ofrecurrence and survival following curative resection gastric cancer.
Br J Cancer 2004;90:206-215
14 Maeda K, Chung YS, Ogawa Y, Takatsuka S, Kang SM, Ogawa M, SawadaT, Sowa M. Prognostic value of vascular
endothelial growth factor expressionin gastric carcinoma. Cancer 1996;77:858-863
15 Japanese Gastric Cancer Association. Japanese classification ofgastric carcinoma- 2nd English Edition.
, 百拇医药
Gastric Cancer 1998;1:10-24
16 陈峻青. 胃癌浆膜的分型及其意义. 中华医学杂志 1986;66:736-738
17 刘庆华, 陈峻青. 胃癌浆膜类型、病理特点与腹腔内游离癌细胞关系的临床研究.
中华肿瘤杂志 1988;10:430-433
18 Chen JQ, Liu QH. Identification and classification of serosalinvasion, as it relates to cancer cells shedding and
surgical treatment in gastric cancer.Semin Surg Oncol 1994;10:107-110
, 百拇医药
19 Wang ZN, Xu HM, Jiang L, Zhou X, Lu C, Zhang X. Expression ofsurvivin mRNA in peritoneal lavage fluid from
patients with gastric carcinoma. ChinMed J (Engl) 2004;117:1210-1217
20 Shimomura K, Sakakura C, Takemura M, Takagi T, Fukuda K, Kin S,Nakase Y, Miyagawa K, Ohgaki M, Fujiyama J,Fujita Y, Nakanishi M, Hagiwara A,Shirane M, Okazaki Y, Hayashizaki Y, Yamagishi H. Combination of
L-3-phosphoserine phosphatase and CEAusing real-time RT-PCR improves accuracy in detection of peritoneal
, 百拇医药
micrometastasis of gastric cancer. AnticancerRes 2004;24:1113-1120
21 Sakakura C, Takemura M, Hagiwara A, Shimomura K, Miyagawa K,Nakashima S, Yoshikawa T, Takagi T, Kin S,Nakase Y, Fujiyama J, Hayasizaki Y,Okazaki Y, Yamagishi H. Overexpression of dopa decarboxylase in peritoneal
dissemination of gastric cancer andits potential as a novel marker for the detection of peritonealmicrometastases
, 百拇医药 with real-time RT-PCR. Br J Cancer 2004;90:665-671
22 Mori K, Aoyagi K, Ueda T, Danjoh I, Tsubosa Y, Yanagihara K,Matsuno Y, Sasako M, Sakamoto H, Mafune K,Kaminishi M, Yoshida T, Terada M,Sasaki H. Highly specific marker genes for detecting minimal gastriccancer cells
in cytology negative peritonealwashings. Biochem Biophys Res Commun 2004;313:931-937
23 Miyagawa K, Sakakura C, Kin S, Nakase Y, Fukuda K, Hagiwara A,Okazaki Y, Hayashizaki Y, Yamagishi H. Over
, 百拇医药
expression of Reg IV in peritonealdissemination of gastric cancer. Gan To Kagaku Ryoho 2004;31:1909-1911
24 陈峻青, 张忠彪, 宫伟, 董明, 杨广育, 李宏. 低渗液、温热对体外培养胃癌细胞系MGC-803杀伤效应的研究.
中华肿瘤杂志 1991;13:97-99
25 董怡民, 陈峻青. 表面活性剂加强双蒸馏水对体外培养胃癌细胞系MGC-803杀伤效应的实验研究.
中华肿瘤杂志 1994;16:318
26 Dai DQ, ChenJQ, Yuan Y, Dong M, Wang MX, Wang SB, Qi CL, Liang HW. The effect ofhypo-osmolar solutions with
, http://www.100md.com
hibitane on shed cancer cells inperitoneal cavity of patients with gastric cancer. Chin J Cancer Res 1995;7:148-152
27 徐惠绵, 陈峻青, 何三光. 温热低渗液、洗必泰、卡铂对胃癌腹膜移植瘤增殖活性的影响.
中华肿瘤杂志 1997;19:270-273
28 陈峻青, 王舒宝, 徐惠绵, 刘庆华, 戴冬秋, 单吉贤, 梁洪伟. 胃癌根治切除并温热低渗液腹腔灌洗的疗效分析.
中华医学杂志 2001;81:730-732
29 Chen JQ, XuHM, Dai DQ, Liu QH, Dong YM, Wang SB. The effect of thermal doubledistilled water on gastric cancer
, http://www.100md.com
cell line and its effect inperitoneal lavage during radical gastrectomy. Chine German J Clin Oncol 2002;1:185-189
30 Yonemura Y, Bandou E, Kinoshita K, Kawamura T, Takahashi S, EndouY, Sasaki T. Effective therapy for peritoneal
dissemination in gastric cancer. SurgOncol Clin N Am 2003;12:635-648
31 王娟, 陈峻青. 卡铂腹腔化疗药代动力学实验研究. 中华肿瘤杂志 1994;16:196-198
32 Yano M, Yasuda T, Fujiwara Y, Takiguchi S, Miyata H, Monden M.Preoperative intraperitoneal chemotherapy for
, http://www.100md.com
patients with serosa-infiltratinggastric cancer. J Surg Oncol 2004;88:39-43
33 Yonemura Y, Kawamura T, Bando E, Takahashi S, Sawa T, Yoshimitsu Y,Obata T, Endo Y, Sasaki T, Sugarbaker PH.
Treatment results of peritonealdissemination from gastric cancer by neoadjuvant intraperitoneal-systemic
chemotherapy. Gan To Kagaku Ryoho 2004;31:1723-1726
编辑 张海宁, http://www.100md.com
戴冬秋,男, 1963-10-04生, 辽宁省凤城市人,蒙古族,中国医科大学医学博士,教授, 主任医师,博士生导师.2000-2002年美国M.D.安德森癌症中心博士后研究员,中国抗癌协会全国胃癌专业委员会委员,《CMJ》及《世界华人消化杂志》等5刊编委及审稿人.主要从事肿瘤外科,化疗及生物治疗等工作,专于胃癌转移分子机制及早期预测与阻断的基础和临床研究.
国家自然科学基金项目,No. 30271477
教育部留学回国人员科研启动基金项目,No. 2002-247
辽宁省自然科学基金项目,No. 972273, No. 001037
, 百拇医药
通讯作者:戴冬秋, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属第一医院肿瘤科、辽宁省胃癌分子病理重点实验室.daidq63@163.com
电话:024-23256666-6227
收稿日期:2005-03-01 接受日期: 2005-03-11
摘要
腹膜复发转移是胃癌根治术后复发的主要形式，成为影响胃癌疗效的关键问题.胃癌腹膜播散转移的形成是一个多因素参与、多阶段的复杂病理生理过程，其中，腹膜亚临床转移的早期预测与及时阻断尤为重要.本文评述了胃癌腹膜转移机制、早诊、预防及治疗的研究进展和策略，着重分析了进展期胃癌根治术后腹膜亚临床转移早期预测方法及预防措施的地位与存在问题.
, http://www.100md.com
关键词:胃癌;腹膜转移; 预测;治疗
戴冬秋.胃癌腹膜转移研究之策略.世界华人消化杂志 2005;13(9):1049-10511 Maehara Y, Hasuda S, Koga T, Tokunaga E, Kakeji Y, Sugimachi K.Postoperative outcome and sites of recurrence in
patients following curative resection ofgastric cancer. Br J Surg 2000;87:353-357
2 Kiyasu Y, Kaneshima S, Koga S. Morphogenesis of peritonealmetastasis in human gastric cancer.
, http://www.100md.com
Cancer Res 1981;41:1236-1239
3 Hagiwara A, Takahashi T, Sawai K, Taniguchi H, Shimotsuma M, OkanoS, Sakakura C, Tsujimoto H, Osaki K,Sasaki S. Milky spots as the implantationsite for malignant cells in peritoneal dissemination in mice.
Cancer Res 1993;53:687-692
4 戴冬秋, 陈峻青, 徐蕾, 赵凤凯, 吴东瑛. 胃癌组织中E-钙黏附素表达的定量检测及临床病理学评价.
中华医学杂志 1997;77:668-671
, http://www.100md.com
5 戴冬秋, 陈峻青, 徐惠绵, 王舒宝, 赵凤凯, 王梅先. E-钙黏附素及a-链接素的表达与胃癌生物学行为及
淋巴结转移规律的关系. 中华肿瘤杂志 2001;23:35-38
6 杨军, 戴冬秋. 胃癌原发灶与转移灶E-钙黏附素mRNA表达水平的比较研究. 中华肿瘤杂志 2005;27:25-28
7 Matsuoka T, Yashiro M, Nishimura S, Inoue T, Fujihara T, Sawada T,Kato Y, Seki S, Hirakawa-Ys Chung K.
Increased expression ofalpha2beta1-integrin in the peritoneal dissemination of human gastriccarcinoma.
, http://www.100md.com
Int J Mol Med 2000;5:21-25
8 Nishimura S, Chung YS, Yashiro M, Inoue T, Sowa M. CD44H plays animportant role in peritoneal dissemination
of scirrhous gastric cancer cells. Jpn JCancer Res 1996;87:1235-1244
9 戴冬秋, 陈峻青, 赵凤凯, 吴东瑛, 王梅先. 细胞黏附分子CD44S、CD44V6在胃癌组织中的表达及其意义.
中华肿瘤杂志 1998;20:376-379
10 徐惠绵, 王剑峰, 王振宁. CEA mRNA、CEA蛋白及细胞学检测胃癌腹腔液中游离癌细胞的初步评价.
, http://www.100md.com
中华肿瘤杂志 2000;22:45-47
11 戴冬秋, 陈峻青, 任常山, 张文范. b-葡萄糖醛酸酶对胃癌诊断及分型意义的研究.
中华肿瘤杂志 1992;14:316-317
12 Yonemura Y, Endou Y, Fujita H, Fushida S, Bandou E, Taniguchi K,Miwa K, Sugiyama K, Sasaki T. Role of MMP-7 in
the formation of peritonealdissemination in gastric cancer. Gastric Cancer 2000;3:63-70
13 Fondevila C, Metges JP, Fuster J, Grau JJ, Palacin A, Gastells A, Volant A, Pera M. p53 and VEGFexpression
, 百拇医药
are independent predictors ofrecurrence and survival following curative resection gastric cancer.
Br J Cancer 2004;90:206-215
14 Maeda K, Chung YS, Ogawa Y, Takatsuka S, Kang SM, Ogawa M, SawadaT, Sowa M. Prognostic value of vascular
endothelial growth factor expressionin gastric carcinoma. Cancer 1996;77:858-863
15 Japanese Gastric Cancer Association. Japanese classification ofgastric carcinoma- 2nd English Edition.
, 百拇医药
Gastric Cancer 1998;1:10-24
16 陈峻青. 胃癌浆膜的分型及其意义. 中华医学杂志 1986;66:736-738
17 刘庆华, 陈峻青. 胃癌浆膜类型、病理特点与腹腔内游离癌细胞关系的临床研究.
中华肿瘤杂志 1988;10:430-433
18 Chen JQ, Liu QH. Identification and classification of serosalinvasion, as it relates to cancer cells shedding and
surgical treatment in gastric cancer.Semin Surg Oncol 1994;10:107-110
, 百拇医药
19 Wang ZN, Xu HM, Jiang L, Zhou X, Lu C, Zhang X. Expression ofsurvivin mRNA in peritoneal lavage fluid from
patients with gastric carcinoma. ChinMed J (Engl) 2004;117:1210-1217
20 Shimomura K, Sakakura C, Takemura M, Takagi T, Fukuda K, Kin S,Nakase Y, Miyagawa K, Ohgaki M, Fujiyama J,Fujita Y, Nakanishi M, Hagiwara A,Shirane M, Okazaki Y, Hayashizaki Y, Yamagishi H. Combination of
L-3-phosphoserine phosphatase and CEAusing real-time RT-PCR improves accuracy in detection of peritoneal
, 百拇医药
micrometastasis of gastric cancer. AnticancerRes 2004;24:1113-1120
21 Sakakura C, Takemura M, Hagiwara A, Shimomura K, Miyagawa K,Nakashima S, Yoshikawa T, Takagi T, Kin S,Nakase Y, Fujiyama J, Hayasizaki Y,Okazaki Y, Yamagishi H. Overexpression of dopa decarboxylase in peritoneal
dissemination of gastric cancer andits potential as a novel marker for the detection of peritonealmicrometastases
, 百拇医药 with real-time RT-PCR. Br J Cancer 2004;90:665-671
22 Mori K, Aoyagi K, Ueda T, Danjoh I, Tsubosa Y, Yanagihara K,Matsuno Y, Sasako M, Sakamoto H, Mafune K,Kaminishi M, Yoshida T, Terada M,Sasaki H. Highly specific marker genes for detecting minimal gastriccancer cells
in cytology negative peritonealwashings. Biochem Biophys Res Commun 2004;313:931-937
23 Miyagawa K, Sakakura C, Kin S, Nakase Y, Fukuda K, Hagiwara A,Okazaki Y, Hayashizaki Y, Yamagishi H. Over
, 百拇医药
expression of Reg IV in peritonealdissemination of gastric cancer. Gan To Kagaku Ryoho 2004;31:1909-1911
24 陈峻青, 张忠彪, 宫伟, 董明, 杨广育, 李宏. 低渗液、温热对体外培养胃癌细胞系MGC-803杀伤效应的研究.
中华肿瘤杂志 1991;13:97-99
25 董怡民, 陈峻青. 表面活性剂加强双蒸馏水对体外培养胃癌细胞系MGC-803杀伤效应的实验研究.
中华肿瘤杂志 1994;16:318
26 Dai DQ, ChenJQ, Yuan Y, Dong M, Wang MX, Wang SB, Qi CL, Liang HW. The effect ofhypo-osmolar solutions with
, http://www.100md.com
hibitane on shed cancer cells inperitoneal cavity of patients with gastric cancer. Chin J Cancer Res 1995;7:148-152
27 徐惠绵, 陈峻青, 何三光. 温热低渗液、洗必泰、卡铂对胃癌腹膜移植瘤增殖活性的影响.
中华肿瘤杂志 1997;19:270-273
28 陈峻青, 王舒宝, 徐惠绵, 刘庆华, 戴冬秋, 单吉贤, 梁洪伟. 胃癌根治切除并温热低渗液腹腔灌洗的疗效分析.
中华医学杂志 2001;81:730-732
29 Chen JQ, XuHM, Dai DQ, Liu QH, Dong YM, Wang SB. The effect of thermal doubledistilled water on gastric cancer
, http://www.100md.com
cell line and its effect inperitoneal lavage during radical gastrectomy. Chine German J Clin Oncol 2002;1:185-189
30 Yonemura Y, Bandou E, Kinoshita K, Kawamura T, Takahashi S, EndouY, Sasaki T. Effective therapy for peritoneal
dissemination in gastric cancer. SurgOncol Clin N Am 2003;12:635-648
31 王娟, 陈峻青. 卡铂腹腔化疗药代动力学实验研究. 中华肿瘤杂志 1994;16:196-198
32 Yano M, Yasuda T, Fujiwara Y, Takiguchi S, Miyata H, Monden M.Preoperative intraperitoneal chemotherapy for
, http://www.100md.com
patients with serosa-infiltratinggastric cancer. J Surg Oncol 2004;88:39-43
33 Yonemura Y, Kawamura T, Bando E, Takahashi S, Sawa T, Yoshimitsu Y,Obata T, Endo Y, Sasaki T, Sugarbaker PH.
Treatment results of peritonealdissemination from gastric cancer by neoadjuvant intraperitoneal-systemic
chemotherapy. Gan To Kagaku Ryoho 2004;31:1723-1726
编辑 张海宁, http://www.100md.com
