【摘要】 目的 探讨白介素-4(IL-4)及白介素-8(IL-8)在慢性阻塞性肺疾病(COPD)发病机制中的作用。方法 搜集32例COPD急性加重期患者，30例COPD缓解期患者和30例健康者的静脉血，离心后取血清，采用酶联免疫法(ELISA)测定其中IL-4及IL-8水平，同时对COPD患者常规测定动脉血PO 2 、PCO 2 以及一秒钟用力呼气容积占预计值百分比(FEV 1 %)，并把它与IL-4及IL-8进行相关性比较。结果 COPD急性加重期患者血清IL-4及IL-8水平明显高于缓解期及健康对照组，且缓解期明显高于对照组，差异有显著性，COPD急性加重期血中IL-4及IL-8含量与PO 2 、FEV 1 %呈负相关，与PCO 2 及吸烟指数呈正相关。结论 IL-4及IL-8参与了COPD气道炎症反应。

    Harbin Thoracic Hospital，Harbin150056.

    【Abstract】 Objective To evaluate the effect of IL-4and IL-8in chronic obstructive pulmonary disease(COPD).Methods We collected serum after centrifuging venous blood from32patients with acute COPD，30paˉtients who were at stable period and30healthy persons，detecting the level of IL-4and IL-8in the serum by ELISA method.At the same time，we estimated PO 2 ，PCO 2 and FEV 1 %of the COPD patients，and then compared their relaˉtions.Results The IL-4and IL-8level of serum

    in patients with acute COPD were obviously higher than in stable period group and healthy group ......