基金项目:吉林省卫生厅科学基金资助项目(编号:96037)

    【摘要】 目的 检测类风湿性关节炎(RA)患者血清抗Sa抗体，并证明抗Sa抗体对RA的诊断意义。方法 采用Western-blot方法。结果 抗Sa抗体诊断RA的敏感度为42.7%，特异度为100%，阳性确诊率为100%，阴性确诊率为71.1%。结论 血清抗Sa抗体对RA诊断的特异度和阳性确诊率均高于类风湿因子(RF)，因此具有临床实用价值。

    关键词 类风湿性关节炎抗Sa抗体 Western-blot方法 类风湿因子

    Detection and clinical significances of anti-Sa antibody in RA serum

    Wang Chang，Wang Jiandong，Zeng Changqian

    Central Hospital of Jilin City，Jilin132011.

    【Abstract】 Objective To detect anti-Sa antibody in rheumatoid arthritis(RA)serum and prove the signifi_ˉcances of seral anti-Sa antibody in diagnostic RA.Methods Western-blot method was used.Results The sensi_ˉtivity，specificity，PPV and NPVwere42.7%，100%，100%and71.1%respectively.Conclusion Diagnostic speci_ˉficity and PPV of seral anti-Sa antibody to RA patients were better than those of rheumatoid factor(RF)and it was practical clinically.

    Key words RA anti-Sa antibody western-blot method RF

    类风湿性关节炎(Rheumatoid arthritis ......