【摘要】 目的根据多囊卵巢形成的机制，建立一种新的多囊卵巢动物模型。方法给9日龄雌性未成年SD大鼠皮下注射丙酸睾丸酮(1.25mg/只)，27日龄再连续9天注射绒毛膜促性腺激素(1.5IU/只)(作为LH的替代物);观察了卵巢形态、血清激素含量。结果 与空白组相比较模型组大鼠卵巢呈现多囊性改变，睾酮(T)升高，LH升高。结论 该模型与人多囊卵巢综合征典型改变相近似，其病理生理过程较为吻合，可用于多囊卵巢综合征实验研究。

    关键词 多囊卵巢动物模型 构建

    Exploration on establishment of polycystic ovary animal model

    You Zhaoling，Feng Guangrong，Tan Zhenyu，et al.

    Department of Integrated Western and Traditional Chinese Medicine，Hunan College of TCM，Changsha410007.

    【Abstract】 Objective According to the formational mechanism of polycystic ovary(PCO)，to build up a new kind PCO animal model.Methods The9days immature female SD rats were injected with1.25mg testosterone proˉpionate of each，then at the27th day1.5IU chorionic gonadotrophin twice daily of each were injected.Ovarian morˉphology and serum hormone were observed.Results In constrast with the control group ......