【摘要】 目的 观察奥沙利铂对胃癌OCUM-2MD3细胞体外的细胞毒活性，以及对胃癌腹膜移植模型的体内抗肿瘤作用。方法 与顺铂(CDDP)比较，用MTT法和药效学体内实验法分别观察奥沙利铂对胃癌OCUM-2MD3细胞的体外细胞毒活性及对胃癌腹膜移植裸鼠的体内抗肿瘤作用。结果 体外实验证明，与CDDP相比，奥沙利铂对人对胃癌OCUM-2MD3细胞的体外细胞毒活性均明显增加(P<0.01)，其两者IC 50 值相比较，L-OHP IC 50
    关键词 胃癌 奥沙利铂 OCUM-2MD3细胞 腹水 抗肿瘤

    Experimental study on anti-tumor effect of L-OHP in vivo

    and vitro on gastric carcinoma cell lines OCUM-2MD3

    Wang Lili，Zhao Qun，Li Yong，et al.

    Department of Surgery，The Fourth Hospital of Hebei Medical University，Shijiazhuang050011.

    【Abstract】 Objective To investigate the cytotoxicity of L-OHP in vitro，and its anti-tumor effect on OCUM-2MD3bearing nude mice in vivo.Methods The cytotoxicity in vitro byMTT assays and the anti-tumor efˉfect on OCUM-2MD3bearing naked mice in vivo by pharmacodynamic methods of L-OHP were tested respectively.Results L-OHP cells possessed a higher antitumor cytotoxic activity on OCUM-2MD3cells in vitro than cisplatin(CDDP);Three groups of naked mice treated with L-OHP were cured(at doses of9mg/kg～2.25mg/kg ......

    百拇医药网 http://www.100md.com/html/DirDu/2005/05/10/57/46/79.htm

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