【摘要】 目的 TGF-β1是一个双向调控因子，可以影响造血干细胞的增生和前质细胞的成熟。还可以抑制成熟B细胞的增生及免疫球蛋白的产生。方法 正常对照组27例，均为健康献血者，血液病患者(包括急性白血病、淋巴瘤、再生障碍性贫血)共24例。应用ELISA法检测TGF-β1水平，独立t检验统计。结果 血液病患者血清TGF-β1水平明显低于正常人。但三组患者之间比较没有显著差异。结论 血清的TGF-β1水平下降可能通过加重原始干细胞缺陷，使其对白血病细胞的生长负调控作用减弱，使其抑制成熟B细胞的增生并促进其凋亡的作用减弱而使血液病病情发展或加重，说明可能与其发病机制有关。

    关键词 TGF-β1 血液病

     【文献标识码】 A 【文章编号】 1680-6115(2004)07-0598-03

    The detection of serum TGF-β 1 in24cases with hematal disease

    Cui Jing，Liu Fuqiang，Wu Yiping

    Beijing Tongren Hospital，Affiliated to the Capital Medical University，Beijing100730.

    【Abstract】 Objective TGF-β1is a multifunctional cytokine，which influences the proliferation of the hematopoietic stem cell and the maturation of progenitor cell，also inhibits the proliferation of matural B cell and proˉduction of immunoglobulin.Methods We compare the level of serum TGF-β1in patients of hematal disease and healthy controls.Results We find that the level of TGF-β1in hematal disease is obviously lower than the controls.Conclusion We believe that lowTGF-β1may aggravate the development of hematal disease by aggravating the defiˉciency of primal stem cell ......