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中药方剂-四君子汤抗精神压力型胃溃疡之研究
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     四君子汤系收载于宋朝太平惠民和剂局方中的传统中药方剂(Traditional Chinese Medicine),它是补脾益气类的代表方剂,对不同原因诱发出的各种脾虚症均具有良好的疗效。由以往的研究成果中知悉四君子汤确实具有抑制精神压力型胃溃疡发生的功效,且此一效果是藉由其能抑制胃酸过份分泌的功效。

    本研究之重点是着重于探讨四君子汤对脑内GABAergic system Serotonergic system等所引起的自发运动及四君子汤抑制胃酸分泌之效果与迷走神经抑或神经化学传递物质之相关联性。由实验结果得知: 将食道两侧的迷走神经切断后,比较给药组及未给药组,其胃液内的游离盐酸量并无显着的差异出现,再经测定大白鼠脑内单胺(Monoamine)含量的变化得知:脑干部位(Brain stem)中的血清紧素(Serotonin :5-HT)及其代谢产物5-hydroxy indole acetic acid (5-HIAA)的含量则呈现出有意义的变化。对于自发运动的测试结果亦可印证出四君子汤亦会影响到脑中GABAergic system及Serotonergic system的作用。
, 百拇医药
    由此一研究成果得知:四君子汤之所以具有预防精神压力型胃溃疡发生之效果,其原因除了能抑制胃酸的分泌之外[SHC1],与脑内神经化学传递物含量的变化有密切的关联性。

    关键词:中药方剂,四君子汤,抗胃溃疡,单胺

    Code Number:CCMP87-RD-005

    Title:Effects of SiJunZiTang on Gastric Ulcer Induced by Psychic Stress in Rat

    Orgazination:Chung-Shan Medical and Dental College

    Auther:Shih hung-che

    SiJunZiTang(S.J.Z.T.) accepted in book of TaiPinHeiMinHoChiChuiFan of Song Dynasty is a Traditional Chinese Medicine. It is believed to be the typical formulation of the wellness of gastric and circulatory systems. For the deficiency of gastric system induced by variable causes, S.J.Z.T. has been proved as its effectiveness. From our previous research, we also evaluated that S.J.Z.T. could inhibit the incidence of stress induced peptic ulcer. This efficacy was achieved by inhibiting of gastric acid.
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    This research is to explore how the S.J.Z.T. affect the GABAergic andSerotonergic System.Also the research was extended to the correlation of inhibition of gastric acid between the treatment of S.J.Z.T. , vagotomy, and neurotransmitters. The S.D. rats were conducted to vagotomized between their esophagus. One group were treated with S.J.Z.T. , the other only received placebo. Results shown that the gastric acid has no significant different between these two groups. However, the amount of monoamine from rat brain, serotonin and its metabolite(5-hydroxy Indole Acetic Acid) from brain stem have been found to be significant different.
, http://www.100md.com
    From this research, we demonstrated that the inhibition of stress-induced peptic ulcer from the treatment of S.J.Z.T. could have several different causes. One is the inhibition of gastric acid, the other one is probably the alteration of neurotransmitter in brain.

    Keywords : Traditional Chinese Medicine, SiJunZiTang, Ant-peptic ulcer, Monoamine., 百拇医药


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