【摘要】 目的 观察牛磺酸(Tau)对大鼠急性脑缺血再灌注损伤的保护作用。 方法 采用大鼠急性不完全性脑缺血再灌注损伤模型，测定脑组织含水量、丙二醛(MDA)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)的含量。 结果 牛磺酸能显著对抗缺血再灌注大鼠脑组织含水量、MDA含量的升高(P<0.05，P<0.01)以及SOD、GSH-Px活性的降低(P<0.05，P<0.01)。 结论 牛磺酸具有保护脑缺血再灌注性损伤的作用，机制与降低脑脂质过氧化和增强氧自由基清除酶的活性有关。

    关键词 牛磺酸 缺血再灌注损伤 超氧化物歧化酶 脑保护作用

    Effects of taurine on acute ischemia reperfusional brain lesion in rats

    Cheng Cailian，Wang Xiaojuan，He Liya，et al.

    Wuhan University of Science and Technology，Medical College，Wuhan430080.

    【Abstract】 Objective To observe the protective effects of taurine against acute brain lesion induced by is-chemia and reperfusional in rats.Methods The contents of water malondislehyde(MDA)and the activities of super-oxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the brain tissue of mice were measured on the cere-bral ischemia-reperfusion lesion model，which was produced by30minutes of common carotid artery ligation follow-ing60minutes and180minutes of reperfusion in rats.Results Taurine significantly antagonized the increase of water and MDA contents(P<0.05and0.01 ......