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新生儿缺氧缺血性脑病免疫状况的研究
http://www.100md.com 《中华中西医杂志》 2005年第9期
缺血性脑病,缺氧缺血性脑病,新生儿,β-内啡肽,免疫
     【摘要】 目的 观察缺氧缺血性脑病患儿的免疫功能。 方法 选择本院儿科住院新生儿缺氧缺血性脑病患儿110例(轻度组40例,中度组38例,重度组32例)和同期健康新生儿30例。新生儿缺氧缺血性脑病患儿随机分成两组:常规治疗组和纳洛酮治疗组各55例。均于住院1~3天、6~7天、12~14天及26~28天采血,分别检测CD3、CD4、CD8、C3、IgA、IgM、IgG各项指标。 结果 住院初与对照组相比新生儿缺氧缺血性脑病患儿免疫功能明显抑制,且与病情严重程度成正比,治疗1周,常规治疗组与对照组比较,CD4、CD4/CD8仍有明显差异(P<0.05),而纳洛酮治疗组和常规治疗组相比,则CD3、CD8、CD4/CD8等项有明显差异(P<0.05)。 结论 新生儿缺氧缺血性脑病患儿免疫功能明显抑制,且与病情严重程度成正比,β-EP参与了其中免疫的抑制性调节。

    【关键词】 缺氧缺血性脑病 新生儿 β-内啡肽 免疫

    Research on changes and mechanism of immunologic function in neonates with hypoxic-ischemic-encephalopathy

    Zhao Hongli,Qin Libo

    Da Qing Oil Field General Hospital,Heilongjiang163001.

    【Abstract】 Objective To observe the dynamic changes of immunologic function(including immunoglobulin,T-cell subpopulation).Methods The hypoxic-ischemic-encephalopathy group contained110cases and control group30cases.The hypoxic-ischemic-encephalopathy group was divided into two sub-groups:routine treatment group(55cases)and naloxone treatment group(55cases).The patients of routine treatment group were treated as sug-gested by Han Yukun etc.The patients in the naloxone group were treated with naloxone for a week in addition to the routine treatment.Two blood samples were collected in each case four times in one month after birth ......

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