【摘要】 目的 探讨趋化因子CCL5(RANTES)在类风湿关节炎(RA)的产生来源。 方法 用酶联免疫吸附法(ELISA)测定28例RA患者血清滑液中CCL5水平，并对患者外周血白细胞和滑液炎性细胞体外产生CCL5进行研究。 结果 RA患者血清和滑液CCL5水平均明显高于OA患者，RA血清CCL5水平与关节肿胀指数、ESR、CRP呈正相关。RA患者滑液炎性细胞体外产生CCL5水平较外周血白细胞高。 结论 血清CCL5水平与RA的活动性病变相关，RA患者滑液炎性细胞是CCL5产生的主要来源。

    【关键词】 关节炎 类风湿 趋化因子 CCL5/RANTES

    Production of CC chemokine CCL5in synovial fluid inflammatory cells from patients with rheumatoid arthritis

    Liu Ningtao，Yang Minghui，Yuan Guohua，et al.

    Dept.of Rheumatology，People's Hospital of Suining，Suining629000.

    【Abstract】 Objective To determine the CC chemokine CCL5(RANTES)level in serum and synovial fluid(SF)from patients with rheumatoid arthritis(RA)，and the expression of CCL5in synovial fluid inflammatory cells.Methods CCL5in serum and SF was quantified by ELISA in28RA patients and21OA patients.The production of CCL5by SF inflammatory cells in vitro was also determined，and compared with that by peripheral white blood cells.Results Serum CCL5level in RA was higher than that in OA，moreover the concentration of CCL5in SFwas greater than in serum in RA.Serum CCL5level correlated significantly with joint swelling index ......