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前列冲剂对吗啡戒断大鼠和抑郁大鼠前列腺组织的病理学影响
http://www.100md.com 《中华中西医杂志》 2005年第10期
前列冲剂,前列冲剂,前列腺,吗啡戒断大鼠,抑郁大鼠,1材料与方法,2结果,3讨论,参考文献
     【摘要】 目的 观察前列冲剂对吗啡戒断大鼠和抑郁大鼠前列腺组织的病理学影响。 方法 将40只雄性大鼠随机分为5个组:正常对照组、吗啡戒断组、吗啡戒断+前列冲剂组、抑郁组、抑郁+前列冲剂组。吗啡戒断组大鼠日皮下注射吗啡后自然戒断,抑郁组大鼠在颈部套一红色圆形项夹。动物模型建立1w后实验组大鼠用前列冲剂灌胃,每日2次,3周后处死大鼠,摘取前列腺,测定腺体重量,计算前列腺指数,常规HE染色观察形态学改变。 结果 前列冲剂降低吗啡自然戒断大鼠前列腺指数,组织学观察前列冲剂明显抑制吗啡自然戒断大鼠前列腺增生,而前列冲剂对抑郁大鼠前列腺指数和前列腺组织的作用不明显。 结论 前列冲剂明显抑制吗啡自然戒断大鼠前列腺组织增生。

    【关键词】 前列冲剂 前列腺 吗啡戒断大鼠 抑郁大鼠

    To study the pathological changes of prostate with Qianlie granute in morphine withdrawal rat and depression rat

    Liao Zeyun

    Department of Physiology,Medical College,Hubei Institute for Nationalities,Enshi445000.

    【Abstract】 Objective To study the pathological changes of prostate with Qianlie granulate in morphine with-drawal rat and depression rat.Methods The rats were apportioned into normal control group,morphine withdrawal group,morphine withdrawal group+Qianlie granulate,depression group,depression group+Qianlie granulate,The rats were subjected to gastric intralipid perfusion for consecutive2weeks.Finally HE stain prostatic tissues section were observed.Results Qianlie granulate could significantly inhibit morphine withdrawal rat prostatic hyperplasia(P<0.05).HE stain prostatic tissues section shows that rat prostatic hyperplasia was inhibited.Qianlie granulate could not significantly inhibit depression rat prostatic hyperplasia.Conclusion Qianlie granulate could significantly inhibit morphine withdrawal rat prostatic hyperplasia. ......

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