【摘要】 目的 观察肾合颗粒对肾阳虚大鼠的治疗作用。 方法 实验采用Wistar雄性大鼠，去势造模，连续给药3周，测定其阴茎勃起潜伏期。取血测定睾酮(T)、一氧化氮(NO)等指标。动物解剖后称包皮腺、精囊腺、前列腺及提肛肌，计算性器官指数。 结果 肾合颗粒各剂量组与模型组比较其阴茎勃起潜伏期明显缩短;NO明显升高;大剂量组T水平与模型组比较有升高的趋势。肾合颗粒各剂量组与模型组比较包皮腺指数明显增加;大剂量组提肛肌指数明显增加;小剂量组精囊腺及前列腺指数有所增加。 结论 肾合颗粒可使阴茎勃起潜伏期明显缩短，NO明显升高，性器官指数明显增加，提示该药具有改善男性性功能障碍的作用。

    关键词 去势大鼠 阴茎勃起潜伏期 一氧化氮 性器官指数

    The dose-finding study of therapeutic effects of Shenhe Keli in rats with asthenia of renal yang

    Ge Zhengyan，Liu Zhiyun，Liu Jianxun

    Xiyuan Hospital，China Academy of TCM，Beijing100091.

    【Abstract】 Objective To observe therapeutic effects of Shenhe Keli by different doses on male animal model with sex dysfunction.Methods Seventy Wistar rats were used and classified to be seven groups.Sixty male rats were castrated to be an animal model of sex dysfunction.Shenhe Keli were administrated daily by oral for consecutive three weeks.After cessation of the treatment ......