彭 永 肖 波 资小宏 冯德云 杨 欢 谢光洁 彭 永 资小宏 410013 长沙 湖南医科大学附属第三医院神经内科；肖 波 杨 欢 谢光洁 附属湘雅医院神经内科 冯德云 病理教研室 中风与神经疾病杂志 1999 0 16 6


    关键词：实验性变态反应性神经炎；凋亡；胸腺细胞；地塞米松；原位末端标记法 期刊 zfysjjbzz 0 论著与经验总结 fur -->


    

摘 要 目的 为了探讨地塞米松对实验性变态反应性神经炎(EAN)小鼠胸腺细胞的影响。方法 应用原位末端标记法和电镜检测EAN小鼠胸腺细胞的凋亡。结果 以上两种方法均发现地塞米松处理组胸腺细胞凋亡率明显高于自然病程组和正常对照组。结论 地塞米松可明显增强EAN小鼠胸腺细胞凋亡。

In situ demonstration of thymocyteapoptosis in thymus during experimental allergic neuritis

Peng Yong,Xiao Bo,Zi Xiaohong,et al.

    Departmnet of Neurology,The Third Affiliated Hospital of Hunan Medical University,Changsha410013.

Abstract Objective Toinvestigate the roles of the dexamethasone DXM on thymocyte apoptosis in kunming mice withacute experimental allergic neuritis (EAN).Methods Using in situ endlabeling (ISEL) techniques,electron microscopy,We investigated the effects thedexamethasone on thymocyte apoptosis among EAN group,DXM group and control group.Result ByISEL investigations,it is revealed that the apoptotic rate of DXM group is highest ofthree groups (P<0.01).These thymocytes appeared an outstanding “apopotic change”underelectron microscopy.Conclusions DXM can enhance thymocyte apoptosis in EAN mice.

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