李沛英 李沛英(272051 山东省济宁市精神病防治院) 临床精神医学杂志 2000 0 10 4


    关键词：精神分裂症；情感性精神障碍；睾酮；雌二醇 期刊 lcjsyxzz 0 195-196 论著 fur -->


    

【摘要】 目的：了解首发精神分裂症和情感性精神障碍患者血清睾酮和雌二醇的变化。 方法：以放射免疫法对首次发病的54例精神分裂症患者和37例情感性精神障碍患者血清中睾酮和雌二醇进行测定，并与正常健康者作对照。 结果：男性精神分裂症患者血清雌二醇浓度显著高于对照组男性，女性情感性精神障碍患者血清睾酮浓度显著高于对照组和精神分裂症组女性。治疗后女性患者血清雌二醇浓度显著下降，对睾酮浓度影响不大。 结论：精神分裂症和情感性精神障碍患者发病早期性激素的分泌尚处于相对稳定状态。精神药物可导致性激素水平不同程度的变化。

A study on serumtestosterone and estradiol levels in patients with first-onset schizophrenia or affectivedisorder

Li Peiying

    (Jining Mental Hospital,Shandong 272051)

【Abstract】 Objective：Toobserve the change of serum testosterone (T) and estradiol (E₂ ) levels beforeand after treatment with psychotropic drugs in patients with first-onset schizophrenia oraffective disorder. Method：Serum T and E₂ were measured with radioimmuneassay in 54 first-onset schizophrenic patients and 37 affective disorder patients. Normalsubjects were recruited as controls for comparision of serum T and E₂ levels. Results：Theserum E₂ level was significantly higher in male first-onset schizophrenicpatients than in male controls, and the serum T level was much higher in female affectivedisorder patients than in female controls or female schizophrenic patients.There weresignicantly decrease in the serum E₂ level in all female patients aftertreatment. Conclusion：The sex hormone level is in relatively stable state in the earlystage of schizophrenia or affective disorder.The psychotroptic drugs could lead to thechange of sex hormone level.

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