提 要 目的： 探讨茶多酚治疗肾炎的机理。方法： 小鼠灌胃茶多酚7天后测其免疫功能和抗氧化酶的活性。结果： 茶多酚可明显抑制小鼠腹腔巨噬细胞及其因子IL-1的活性和NO的生成；抑制小鼠脾细胞产生抗体的能力和血清CIC的含量；抑制小鼠脾细胞增殖反应和总T细胞花环和T_H 花环的形成。茶多酚还可增强小鼠红细胞SOD和血中GSH-PX的活性，抑制血清中LPO的生成。结论： 茶多酚抑制小鼠免疫功能、增强小鼠抗氧化酶的活性可能是其治疗肾炎的机理之一。

Dong Qun, Wu Minyu, Qu Weimin, Liu Hui, Sun Ruiyuan

    (Department of Microbiology,Wannan Medical College, Wuhu 241001)

Object : To study the mechanism of curinganti-membrane glomerulonephritis by Tea Polyphenol (TP). Method : Givenorally TP of different dosage to mice for 7 days, the mice' immune function and enzymeactivity correlating anti-oxygenation were detected. Result : TP coulddecrease the activities of peritoneal MΦ and IL-1, and the formation of nitric oxide(NO). TP could inhibit the antibody formation of spleen cell and the content of CIC insera, and evidently decrease the percentage of the rosettes of T cell and T_H cell, and proliferative reaction of spleen cell. TP could increase the activities of SODin RBC and GSH-P_X in blood, decrease the content of LPO in sera.Conclusion :TP could inhibit immune function of mice and promote the enzyme activities ofanti-oxygenation.

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