Li Yu Xiong Daishui Gao Min LiDianhong

    (Guangdong Provincial Institute of Traditional Chinese Medicine,Guangzhou 510095)

    Hu Xiaoke

    (Department of Nuclear Medicine,Sun Yat-sen University of Medical Science,Guangzhou510089)

Abstract Objective:To study the effectof coixenolide (CXL) on irradiation to human nasopharyngeal carcinoma cell lineCNE-2Z.Methods:Microcolony formation assay was used in determining sensitivity of CNE-2Zto γ-ray in vitro.Results:CXL shifted the radiation dose-survival curve to the left,withthe decrease of D₀ and D_q values.Radiation dose was reduced by 7.45%～17.3%at D₃₇ level,the sensitizing enhancement ratios (SER)were 1.11～1.46 and 1.02～1.11at D₀ and D_q levels,respectively,when CNE-2Z was treated with 10^-7 ,10^-6.5 and 10^-6 mol/L of CXL.Conclusion:CXL can increase susceptibility of CNE-2Z toirradiation.

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