周宏 曲冬梅 王进雪 周宏(山东省聊城市人民医院，聊城市252000)；王进雪(山东省聊城市人民医院，聊城市252000)；曲冬梅(中国协和医科大学，北京100730) 基础医学与临床 2000 0 20 2


    关键词： 期刊 jcyxylc 0 集落刺激因子临床研究进展专题 fur -->


    

中图分类号：R331.14 文献标识码：A

    文章编号：1001-6325 (2000)02-0012-05

Abstract：Thrombopoietin(TPO) actsprimarily as a megakaryocytic lineage-specific hematopoietic growth factor through aspecific cell surface receptor encoded by c-Mpl proto-oncogene .It has been shownsuccessfully to stimulate megakaryocytic development from CD34+ precursor cells，megakaryocyticproliferation and enlargement both in vitro and in vivo.Then，platelet(PLT)production will be increased.TPO also plays a role in mobilization of erythroid andmyeloid progenitor cells.It works with a dose-dependent manner on the PLT number.TPOcan reduce the degree and duration of chemotherapy or radiation induced thrombocytopeniaboth in animals and in human.And it has on effect on platelets count in volunteer PLTdonors and the number of peripheral progenitors transplantation.No severe complicationsoccur during TPO use in clinic trials.So it may be practiced in clinic medicine in thenear future ......

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