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Abstract Individualsusceptibility to cancer induced by environmental agents may be influenced by polymorphicmetabolic genes responsible for the activation or detoxification of carcinogens.Theassociation between genetic polymorphisms in cytochrome P4501A1 (CYP1A1) and lung cancersusceptibility has been extensively studied.The various CYP1A1 alleles exhibitpopulation frequencies that depend on race and ethnicity.An increased risk of lungcancer in Asians was found to be associated with genetic polymorphisms in CYP1A1.However，reportsfrom Caucasians are not consistant，probably suggesting the ethnic-sepecific effect ofthe polymorphisms in the locus on the cancer.Evidence also exists for the associationbetween levels of carcinogen-DNA adducts or frequency of oncogene and tumor suppressorgene mutations and CYP1A1 polymorphisms.These findings provide a better understanding ofthe relationship between CYP1A1 and lung cancer susceptibility.
肺癌是最常见的恶性肿瘤之一 ......
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