陈斌 佘熙滇 刘永忠 王亚兵 陈斌(皖南医学院附属弋矶山医院 安徽省芜湖市241001)；佘熙滇(皖南医学院附属弋矶山医院 安徽省芜湖市241001)；刘永忠(皖南医学院附属弋矶山医院 安徽省芜湖市241001)；王亚兵(皖南医学院附属弋矶山医院 安徽省芜湖市241001) 中国肿瘤临床 2000 0 27 2


    关键词：胃癌；细胞间粘附分子-1；酶联免疫吸附试验 期刊 zgzllc 0 98??100 论著 fur -->


    

摘要 目的：探讨血清可溶性细胞间粘附分子-1(sICAM-1)水平与胃癌临床病理指标的关系，评价检测胃癌患者sICAM-1的临床意义。方法：应用酶联免疫吸附法分别检测34例治疗前胃癌患者及20例正常人血清中可溶性细胞间粘附分子-1的含量。结果：胃癌组及正常人对照组血清sICAM-1含量分别为367.7±104.7ng/ml，236.9±74.3ng/ml，两者有显著差异

Serum Levels of Intercellular Adhesion Molecule- 1 in Patients with Gastric Cancer

Chen Bin She Xidian Liu Yongzhong et al
(Yijishan Hospital of Wannan Medical College, Wuhu)

Abstract Objective : To study the relationship between the serum soluble intercellular adhesion molecule - 1 (sICAM- 1) and the clinicopathological features, and to evaluate the possible prognostic significance of sICAM- 1 concentration in gastric cancers. Methods : Thirty- four patients with gastric cancer were prospectively evaluated. The control group consisted of 20 healthy volunteers. Serum concentrations of ICAM- 1 of them all were measured by the quantitative sandwich enzyme immunoassay technique. Results : The mean value of serum ICAM in patients with gastric cancer was 367.71+ 104. 7 ng/ml and that of the control group was 236.9+ 74.3 ng/ml, and the difference was significant (P< 0.001). The patients with the tumor size equal to or more than 5cm had significantly higher serum concentration of ICAM- 1 than those with smaller ones (406.7+ 90.2ng/ml vs 319.9 + 105.3 ng/ml) (P< 0.01). Compared the early stage (Ⅰ ～ Ⅱ ) patients with more advanced clinical stage patients (Ⅲ ～ Ⅳ ), the latter had a higher level of sICAM- 1 (397.1+ 102.4ng/ml vs 306.0 + 82.3ng/ml) (P< 0.05). There was also a statistically significant difference in sICAM- 1 levels between patients with positive lymph node status and those without (403.6+ 99.7ng/ml vs 302. 7+ 81.4ng/ml) (P< 0.01). No relation was observed between the level of sICAM- 1 and the grade of histological differentiation in patients with gastric cancer. Conclusion : Evaluation of sICAM-1 concentration may be a valuable parameter for predicting the prognosis and degree of cancer in gastric cancer patients.
Key Words Stomach neoplasm Intercellular adhasion molecule - 1 Enzyme- linked immunosorbent assay

细胞间粘附分子-1(ICAM-1)属免疫球蛋白超家族一成员 ......