摘要 目的： 探讨雄激素对尿石症患者的影响。方法： 用体积分数为0.5%乙二醇诱导结石形成；建立4组动物实验雄鼠模型。A组：去势结石组；B组：去势加皮下注射睾丸酮(3mg/d)结石组；C组：结石对照组；D组：正常对照组(标准无结石饮食)。4组雄鼠饲养4周后同时宰杀，分别测定和比较他们血清Testo，FSH，LH，E2，PRL，Prog；单侧肾质量，肾内钙、镁、磷含量。结果： B组肾内钙含量明显高于A组。结论： 雄性激素对尿石症有一定影响，它能增加实验鼠肾组织内钙的沉积。

    中国图书资料分类法分类号 R692.4，R589.9

A STUDY OF RELATIONSHIP BETWEEN MASCULINE HORMONE AND UROLITHIASIS

Qin Weiwu,Lu Shaoming,Wu Bo,et al

    (Department of Nuclear Medicime,the First Hospital of Guangxi Medical University, Nanning 530021)

ABSTRACT Objective: To investigate testosterone in the pathogenesisof urolithiasis.Methods: We did animal experiment. Adult winstar male ratswere divsded into 4 groups of to rats each.One group(D) was left untreated and served asnormal contols.The other 3 groups of rats were fed with 0.5% ethylene glycol(EG)lithogenic diet for 4 weeks. Among them Group A was castrated;Group B was castrated andthen subcutaneously injected with Testo(3mg/day);Group C was left untreated and served asstone cnotrols. Serum Testo. FSH. LH. Prog. PRL. E2. And Ca²⁺ .Mg²⁺ .P³⁺ in rat kidney were determined.Results: Ca²⁺ in kidney of GroupA were less than Groups B.Conclusion: Testo had certain influence on urolithiasis. It could enchance the amount of Ca²⁺ in EG-induced male ratkidney.

     ......