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关键词：胸膜病变；可溶性细胞间粘附因子；酶联免疫吸附测定
摘要 目的： 通过检测结核性胸膜炎及癌性胸液患者血清中可溶性细胞间粘附因子-1(sICAM-1)的水平，探讨其临床意义。方法： 采用酶联免疫吸附试验(ELISA)。操作按药盒说明书进行。结果： 结核性胸膜炎患者血清sICAM-1水平为(523±77)μg/L，癌性胸液患者为(348±53)μg/L，正常人血清则为(262±34)μg/L。结论： sICAM-1参与了结核性胸膜炎的病理过程，同时可能介导了肿瘤的转移，但癌性胸水患者的sICAM-1表达较结核性患者为低下，存在着sICAM-1表达的缺陷。
中国图书资料分类法分类号 R521.5；R734
CLINICALSIGNIFICANCE OF DETECTING sICAM-1 OF SERUM
Wu Cong,Lu Guanrun,LiuGuangnan,et al
Department of Respiratory Diseases,FirstAffliated Hospital of Guangxi Medical University,Nanning 530021
Abstract Objective： To evaluate theclinical significance of detecting sICAM-1 of serum.Method： sICAM-1 ofserum in 20 patients with tuberculosis pleurisy,18 patients with lung cancer involvingpleura and 19 health controls was detected by ELISA method.Result： sICAM-1of serum in patients with tuberculosis was much higher than that of serum in lung cancerpatients and healthy controls(P<0.05).sICAM-1 of serum in patients with lung cancer wasalso much higher than that in healthy control.Conclusion： sICAM-1 mightinvolve in the pathologic process of tuberculosis pleural effusion,and so do in the spreadprocess of lung cancer.The expression of sICAM-1 of serum in lung cancer patients was muchless than that in patients tuberculosis pleurisy.It suggested that there was an expressiondeficiency of sICAM-1 in patients with lung cancer.
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