关键词：巨细胞病毒感染；白血病；肺炎；抗原
摘要 目的： 了解白血病患儿巨细胞病毒(CMV)肺炎的发生状况及CMV抗原血症检测方法对CMV肺炎的诊断意义。方法： 实验组为31例白血病患儿，对照组为31例免疫功能正常的儿童，应用间接免疫荧光方法检测外周血白细胞CMV抗原；应用ELISA方法检测血清抗CMV-IgM、IgG抗体。结果： 白血病患儿中有9例发生活动性CMV感染，感染率为29.1%，对照组为0，两者之间差异显著(P<0.01)。9例活动性CMV感染患儿中，有6例为肺炎，临床表现无特异性，胸片表现多样化，病情轻重不一。6例CMV肺炎患儿检测CMV抗原血症均为阳性。结论： 白血病患儿易发生CMV肺炎。CMV抗原血症检测技术可早期诊断白血病患儿CMV肺炎，为临床早期治疗提供实验依据。
ANTIGENEMIA ASSAY FOR DIAGNOSING
CYTOMEGALOVIRUS PNEUMONIA IN LEUKEMIA CHILDREN
An Jing,Shen Kunling,Wu Minyuan,et al
(Department of Cytobiology,Institute of Clinical Sciences;
Pediatric Research Institute and Department of Hematology,Beijing Childrens Hospital)
Abstract Objective ： To evaluate the incidence and clinical course of cytomegalovirus(CMV) pneumonia in leukemia children and the significance of CMV antigenemia assay for diagnosing CMV pneumonia.Methods ： Thirty one leukemia children and 31 immunocompetent control children were involved in the study. Indirect immunofluorescence assay was used for detecting CMV antigen in peripheral blood leukocytes,ELISA for anti-CMV IgM and IgG.Results ： Active CMV infection was diagnosed in 29.1%(9/31) leukemia children while none in control group.Active CMV infection rate showed a significant difference between these two groups(P<0.01).Six out of nine CMV infected patients had CMV pneumonia during the period of induction phase.There were no specific clinical patterns of CMV pneumonia,but the chest X-ray showed different manifestations and different severity.CMV antigenemia occurred in all of the six patients with CMV pneumonia.Conclusion ： CMV infection was common in leukemia children.Pneumonia is one of the most common diseases of CMV infection.CMV antigenemia assay is a rapid diagnostic technique which can identify patients likely to develop CMV pneumonia,potentially allowing early treatment.
Subject headings ： cytomegaloviruses;leukemia;pneumonia;antigens
白血病患儿由于疾病本身以及化疗和输血等因素 ......
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