摘要 目的：观察前列地尔脂微球载体制剂(凯时，北京泰德制药有限公司)对下肢慢性动脉缺血症的疗效。方法：以多中心、同步、等样本、开放性给药方法，应用前列地尔脂肪乳注射液治疗47例下肢动脉缺血症患者，采用小剂量(10 μg/d)，一次静脉推注，连续14 d。于用药前后分别观察患者的间歇性跛行、皮肤感觉、静息痛和溃疡情况，并计算踝/肱指数。结果：患者间歇性跛行、皮肤感觉、静息痛、溃疡和踝/肱指数改善的有效率分别为57.5%、74.5%、81.1%、43.4%和23.5%，综合疗效评价有效率为83.0%。结论：前列地尔脂微球载体制剂治疗下肢慢性动脉缺血症效果显著，副作用低。

    

EFFICACY OF LIPO PGE₁ IN TREATMENT OF 47 PATIENTS

    WITH CHRONIC ARTERIAL ISCHEMIA OF LEG

Huang Xiaozhong,An Zheng,Zhang Baigen,et al

    (Renji Hospital of Shanghai 2nd Medical University,200001)

Abstract Objective：To evaluate an efficacy of Lipo prostaglandin E₁ (PGE₁ ) in the treatment of chronic arterial ischemia of legs.Methods:Lipo PGE₁ was adopted to treat 47 patients with chronic arterial ischemia of leg(35 patients with arteriosclerosis obliterans,seven with thromboangiitis oblitorans,five with diabetes).A dosage of 10 μg of Lipo PGE₁ was given intravenously once a day,14 days for one course.Results:The efficacy of intermittent claudication,the sence of skin,resting pain,ulcer and ankle humeral index are 57.5%,74.5%,81.2%,43.4% and 23.5% respectively with a total efficacy of 83.0%.Conclusion:Lipo PGE₁ can be used in the treatment of chronic arterial ischemia of legs with a marked improvement of numbness,hypesthesia,sensation of cold and pain in lower limbs.

    Subject headings:prostaglandins E,synthetic;infusions,intravenous;peripheral vascular diseases

    

1998年2月～1998年5月间 ......