摘要 目的：研究异丙酚对快速起搏预适应的缺血心肌保护效应的影响。方法：24只白兔随机分成缺血对照，起搏缺血和异丙酚+起搏缺血组。结果：起搏组全心缺血30分钟再灌30分钟时左室收缩功能(LVDP、+dp/dt_max )及舒张功能(-dp/dt_max )的恢复明显优于缺血对照组(P<0.05)，起搏期间给予异丙酚10μmol/L，使缺血后LV+dp/dt_max ，LVDP和LVEDP的恢复幅度显著差于起搏缺血组(P<0.05)，且再灌注30分钟末LDH，CPK活性和ADP含量明显高于起搏缺血组，ATP含量则低于上述组。结论：异丙酚可缓解快速起搏即刻的心肌挛缩，但却消除其对缺血心肌的预适应效应。

    Propofol eliminates the protective effect of heart pacing-induced preconditioning on the isolated ischemic myocardium Mao Weike，Yuan Shiying，Yao Shanglong.Department of Anesthesiology，Union Hospital，Tongji Medical University，Wuhan 430022

    Abstract Objective：To study the effect of propofol on the protection of ischemic isolated heart preconditioned by rapid heart pacing.Method：24 white rabbits were assigned randomly into ischemia control(IC) ......