关键词：肠源性囊肿；形态学；免疫组织化学
摘要 目的：观察中枢神经系统肠源性囊肿的组织形态及免疫组织化学特征。方法：使用病理组织学及免疫组织化学方法对31例中枢神经系统不同部位的肠源性囊肿进行研究。结果：囊肿壁上皮可为单层或复层扁平、立方、柱状上皮；一些病例可见两种以上上皮组织成分，并相互移行；某些病例，在囊肿壁内可含有黑色素、软骨、平滑肌、粘液腺等多种组织成分。免疫组织化学染色EMA均呈阳性；CEA染色仅一例阴性，而此例NSE阳性，故应诊断为神经上皮性囊肿；S-100和CK染色结果不固定；Vimentin和GFAP均呈阴性。结论：肠源性囊肿的组织形态和免疫组织化学特点可作为鉴别其他类型囊肿的依据。
Morphologic andimmunohistochemical study of enterogenous cyst in the central nervous system Yue Shenglin, Fang Jingyi, LuoLin, et al. Department of Neuropathology, Beijing Neurosurgical Institute, Beijing 100050
Abstract Objective: To study thecharacteristics of histology and immunohistochemistry of enterogenous cyst in the centralnervous system. Methods: Histopathological and immunohistochemical examinations wereperformed in 31 cases. Among these patients, their ages ranged from 1.5 to 58 years.Results: Enterogenous cyst are most commonly observed in young persons. Histologicalfindings are different from the previous literatures. The cyst walls were lined by asimple or stratified of squamous, cuboidal or columnar epithelium. In some cases, thereare two or more epithelium types which transmigrate each other. Visceral muscle, mucousgland and other components within the cyst wall can be found in some cases. All theenterogenous cyst epithelia present EMA immunoreactivity. One of the cases shows CEAnegative but NSE positive staining, so it suggested to be a neuroepithelial cyst. S-100and CK immunostaining occurred irregularly in these cases. All the cases did not showVimentin and GFAP staining. Conclusion: These characteristics of enterogenous cyst arehelpful in distinguishing their type from others.
Key words Enterogenous cyst Morphology Immunohis chemistry
中枢神经系统肠源性囊肿是少见的先天性瘤样病变 ......
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