【摘要】 目的 探讨造影剂导致肾血管张力改变的机理及其条件，以及内皮素和一氧化氮(NO)在其中的作用。方法 采用离体灌流大鼠肾动脉直径测定，观察在不同造影剂、内皮素(ET)、NO及其它药物的刺激下，肾动脉直径的变化。结果 造影剂能够显著地、特异性地提高大鼠肾动脉对ET缩血管作用的敏感性，此作用主要由ETA受体介导，与渗透压无关；造影剂能够显著地、特异性地降低大鼠肾动脉对NO扩张血管作用的敏感性，这一作用主要与渗透压有关。结论 造影剂能特异性地改变大鼠肾动脉对ET及NO作用的敏感性。

LI Song, GAO Yuangui, DONG Baowei.TheGeneral Hospital of PLA,Beijing 100853

【Abstract 】 Objective Toinvestigate the mechanism and conditions of the influences of contrast media on renalvascular tone, and the role in which endothelin and NO may play. Methods The experiment was conducted by measuring the diameter of isolatedperfused rat renal artery. The changes in diameter were observed as the arteries weresuperfused with contrast media, endothelin, NO and other agents. Results Contrast media significantly and selectively enhanced the arterialsensitivity to endothelin. This alteration was mediated by ETA receptor and was notinfluenced by osmolarity. Contrast media significantly and selectively decreased thearterial sensitivity to NO, which was mainly induced by osmolar charges. Conclusion Contrast media can selectively alter the sensitivity of renalarteries to endothelin and NO.

     【Key words 】 Contrast media Endothelin Nitric oxide

经血管放射造影剂可能导致急性的肾功能损害 ......