摘要 目的: 了解儿童急性髓系白血病的临床特点、治疗疗效及预后因素。方法: 对1978年8月～1995年12月274例儿童急性髓系白血病进行临床总结和分析。结果和结论: 中位确诊年龄7岁3个月,男∶女=1.63∶1,M₂ 、M₃ 型占80%,高白细胞血症20例,髓外白血病24例,有Auer小体者占32.9%。治疗244例,分别以三种方案进行治疗,完全缓解(CR)率55.88%～92.31%,证明采用DA或DA+Vm26或Vp16是提高CR的关键。影响诱导缓解因素为病初白细胞计数和肝脾肿大程度。通过SPSS统计学软件分析,AML亚型、Auer小体、诱导缓解时间、髓外白血病等因素对远期预后有影响。

    Clinical study of childhood acute myelogenous leukemia ZhaoXinmin,Hu Yamei,Zang Yan,et al.Beijing Childrens Hospital，Beijing 100045

    Abstract Objective: To investigate the clinicalcharacteristics,treatment responsiveness and prognostic factors of childhood acutemyelogenous leukemia.Methods： Two hundred and seventy-four children withacute myelogenous leukemia diagnosed between 1978 and 1995 were retrospectively analyzed.Resultsand conclusions： Male∶female is 1.6∶1.The median age was 7.25 years. M₂ and M₃ were the commonest subtypes( 80%).Twenty cases were hyperleukocytosisand 24 with extramedullary involvement.Thirty two percent of the patients was Auer rodspositive.Two hundred and forty-four patients received combination chemotherapy.Complete remission(CR) rates varied from 55.88% to 92.31%.Intensive chemotherapy(includingDA,DA+Vm26 or Vp16) was the cornerstone for high CR rate.Other factors influencing CR ratewere initial WBC count and hepatosplenomegaly.

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