【摘要】 目的 研究下食管括约肌(LES)局部组织内一氧化氮(NO)和血管活性肠肽(VIP)含量与LES压力(LESP)的关系。方法 检测了108例食管运动功能障碍性疾病患者LES局部组织内NO和VIP含量及LESP。结果 LESP与组织内NO和VIP含量呈负相关(r=-90.7,P<0.01；r=-92.3,P<0.01),NO和VIP含量之间呈正相关(r=88.5,P<0.01)。结论 胃食管反流性疾病(GERD)和贲门失弛缓症患者LES局部组织内NO和VIP含量异常，并且两者之间相互影响，相互作用，共同参与了LESP的调节和GERD及贲门失弛缓症的病理生理过程。

    

Relations of nitric oxide andvasoactive intestinal polypeptide with lower esophageal sphincteric pressure

XIE Yong,HUANG Yuan,WANG Chongwen,et al.

    First Affiliated Hospital of Jiangxi Medical College,Nanchang330006

【Abstract】 Objective Theeffect of contents of nitric oxide ( NO ) and vasoactive intestinal polypeptide ( VIP ) onlower esophageal sphincteric ( LES ) pressure was estimated.Methods 108cases with esophageal motor disorders were included , in each case the amounts of NO, VIPand pressure of LES tested. Results Negative correlation was notedbetween LES pressure and tissue concentrations of NO and VIP (r= -90.7, P<0.01; r=-92.3, P<0.01) While the latter two related positively each other (r=88.5, P<0.01) .Conclusion NOand VIP at LES were abnormal in amount in patients with gastroesophageal reflux disordersand cardiac achalasia , participated reciprocally in regulating LES pressure andpathophysiology of the two disease patterns .

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