摘要 为研究粘附分子在溃疡性结肠炎(UC)发病机制中的作用，应用流式细胞术测定34例UC患者活检组织及血液中粘附分子CD₄₄ 及细胞间粘附分子CD₅₄ ，并与20例正常人对照。结果显示，UC患者组织和血液中CD₄₄ 、CD₅₄ 较正常人明显升高(P<0.01)，缓解期UC患者上述指标较活动期显著下降(P<0.05)，但仍明显高于正常人(P<0.05)。本文结果提示粘附分子水平增加在UC的发病机制中起重要作用，对判断或监测UC患者病情进展及活动转归具有一定意义。

    

EXPRESSION OF ADHESION MOLECULES ON TISSUES AND PERIPHERAL LYMPHOCYTES IN PATIENTS WITH ULCERATIVE COLITIS Jiang Xueliang, Quan Qizhen, Chen Guiyong, et al. Department of Gastroenterology, Chinese PLA General Hospital of Jinan Command Area, Jinan 250031

    Abstract To study the expression of adhesion molecules on tissues and peripheral lymphocytes in patients with ulcerative colitis(UC), CD₄₄ ,CD₅₄ were assessed using flow cytometry in 34 UC patients and 20 healthy volunteers. Results showed that increments of CD₄₄ on tissues and blood cells in UC were 20.3±8.2% and 19.4±6.3% respectively, that of CD₅₄ being 37.2±8.9% and 18.3±8.9% as compared with the controls′(9.7±4.6%,7.8±4.5%,8.8±4.2% and 6.2±3.7% correspondingly, P<0.05). With regression of UC the above indexes though declined in degree, remained still higher than controls′ (P<0.05). Regarding CD₄₄ no significant difference was detected on tissues than on blood cells except in patients with severe hyperplasia, suggesting that increase in adhesive molecules plays an important role in pathogenesis of UC. Its determinations may be helpful to predict the prognosis of UC.

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