刘亮 鲁焕章 丁洁 李继坤 李学杰 300100 天津南开医院 中华消化内镜杂志 1999 0 16 5


    关键词：腹腔镜胆囊切除术；免疫试验 期刊 zhxhnjzz 0 论 著 fur -->


    

摘要 目的 研究腹腔镜胆囊切除术(LC)和开腹胆囊切除术(OC)对机体免疫功能的影响。方法 监测70例(LC及OC各35例)胆囊结石患者术前、术后第一天、术后第三天的外周血淋巴细胞(PBL)亚群、补体C3及白细胞介素-6(IL-6)和肿瘤坏死因子(TNF)的变化并行对比研究。结果 OC组术后第三天成熟的T淋巴细胞(CD3)、辅助性T细胞(CD4)、CD4/抑制性T淋巴细胞(CD8)比值较术前明显下降(P<0.05或P<0.01)，且两组相比较，OC组明显低于LC组(P<0.01)，OC组术后第一天或/和第三天C3、IL-6、TNF较术前明显升高(P<0.01)。且两组比较OC组明显高于LC组(P<0.01)。结论 LC对机体免疫及细胞因子水平影响较小，这构成了LC术后恢复较快的病理生理基础。

    

Effect of laparoscopic cholecystectomy and open surgery on immune system

LIU Liang, LU Huanzhang, DING Jie, et al.

    Tianjin Nankai Hospital, Tianjin 300100

Abstract Objective The consequences of laparoscopic cholecystectomy(LC) and open cholecystectomy(OC) exerted on human immune system were reported. Methods Multiple immunoassays were tested and compared postoperatively in each of 35 patients after LC or OC under general anesthesia. Results Postoperative levels of CD3, CD4 and CD4/CD8 in cases having had OC decreased significantly than those undergoing LC ( P<0.05 and P<0.01 ). Whereas the concentrations of complement C3, interleukin-6(IL-6)and tumor necrosis factor(TNF) of the former increased evidently ( P<0.01 ) than the latter. Conclusion It is suggested that LC impose less influences on immunoassays with sooner recovery to preoperative levels.

    Key words Laparoscopic cholecystectomy Immunoassays

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