【摘要】 目的 探讨p16抑癌基因在小儿肾母细胞瘤的表达和临床分期、病理类型、预后之间的关系。 方法 采用S-P免疫组化法，对51例肾母细胞瘤组织切片进行p16抑癌基因检测。 结果 17例呈阳性表达，阳性率为33%，阳性表达与肿瘤分期无明显相关(P>0.05)，但与病理类型、患儿预后明显相关(P<0.05)，阳性表达者预后好，多为上皮型、混合型。 结论 肾母细胞瘤患儿p16基因表达阳性者预后好，p16基因可作为判定肾母细胞瘤预后的一项指标。

et al.Department of Pediatric Surgery,the2nd Clinical College,China Medical University,Shenyang 110003

【Abstract】 Objective To studythe relationship between expression of suppressor gene p16 and clinicalstaging,pathological typing and prognosis in nephroblastoma. Methods 51 cases ofnephroblastoma have been studied by SP immunohistocheminal technique (IHC). Results 17 caseswere positive and the positive rate was 33%.There was no correlation between positivecases and clinical staging,but was significantly related to the pathological typing andprognosis.Prognosis is better in positive cases than that in negative cases. Conclusions Theprognosis is good in children with positive expression of p16 gene in nephroblastoma andtherefor p16 gene detection can be used as a marker to predict the prognosis of nephroblastoma.

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