谢庆祥 裴发光 孟家榕 汪鸿 缪友仁 谢庆祥、汪鸿、缪友仁(363000 漳州，解放军第一七五中心医院泌尿外科)；裴发光、孟家榕(病理科) 中华泌尿外科杂志 1999 0 20 5


    关键词：前列腺增生,免疫组织化学,增殖细胞核抗原 期刊 zhmnwkzz 0 论 著 fur -->


    

【摘要 】 目的 探讨前列腺增生(BPH)手术标本的组织形态及其细胞增殖状态的区域分布特征。 方法 应用HE染色和免疫组化染色结合计算机辅助图像分析方法，对24例BPH手术标本的三个区域中组织构成和增殖细胞核抗原(PCNA)表达进行定量分析。 结果 间质面积百分比和间质/上皮比值在尿道周围区、中间区和包膜下区中均依次递减(P <0.01)，而上皮和腺腔面积百分比则依次递增(P <0.01)；三区间腺腔/上皮比值差异无显著性。尿道周围区PCNA指数高于其它两区(P <0.05)。 结论 BPH的组织构成和细胞增殖状态存在着区域分布差异。

Regional morphosis and quantitativedistribution of the index of PCNA in benign prostatic hyperplasia XIE Qingxiang ,PEI Faguang MENG Jiarong ,etal .Department of Urology ,the 175 Hospital of PLA ,Zhangzhou 363000

【Abstract 】 Objective Toexplore the regional distribution characteristic of morphosis and cellular proliferationin benign prostatic hyperplasia(BPH). Methods The HE staining andimmunohistochemistry combining with computer-assisted quantitative image analysis systemwere adopted to examine the mean percent area densities of stroma,epithelium and glandularlumen and the index of PCNA among periurethral zone,intermediate zone and supcapsular zoneof prostate specimens from 24 patients with BPH. Results Both thearea density of stroma and the ratios of stroma to epithelium were the highest in theperiurethral zone and the lowest in the supcapsular zone. While the area density ofepithelium and glandular lumen in the periurethral zone was significantly lower than thoseof peripheral zones.The ratios of glandular lumen to epithelium among three zones were notstatistically different. There were significant differences of the index of PCNA amongthree zones. Conclusions Regional distribution differences ofmorphosis and PCNA index in BPH tissues were observed.

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