摘要 为研究幽门螺杆菌(Hp)感染对胃粘膜上皮细胞增殖和凋亡的影响，探讨胃粘膜上皮细胞增殖与细胞凋亡之间的关系，采用脱氧核糖核酸末端转移酶介导的dUTP缺口末端标记(TUNEL)技术、增殖细胞核抗原(PCNA)免疫组织化学染色对Hp阳性患者Hp根除前后及Hp阴性者胃粘膜上皮中增殖细胞、凋亡细胞进行原位观察和比较。结果Hp阳性患者胃粘膜细胞增殖指数、凋亡指数均显著增加，Hp根除后，上述指标均显著降低，而Hp仍为阳性者上述指标则无显著性变化。胃粘膜细胞增殖指数与凋亡指数呈显著正相关。提示Hp诱导胃粘膜上皮细胞凋亡可能是刺激胃粘膜上皮细胞过度增殖的机制之一，使胃粘膜的不稳定性增加，从而增加患胃癌的危险性。

    

EFFECT OF HELICOBACTER PYLORI ON GASTRIC EPITHELIAL CELL
PROLIFERATION AND APOPTOSIS Liu Haifeng，Liu Weiwen，Fang Dianchun，
et al.Department of Gastroenterology，South-West Hospital Military Medical University
，Chongqing 400038

    Abstract This study was attempted to have an understanding of relationship
between Helicobacter pylori (Hp) and proliferation as well as apoptosis of
gastric epithelid cells ......