Objective This paper investigated mainly on the role of PAF in the hemodynamic changes during endotoxemia and the protective effects of PAF receptor antagonist.

    Methods Forty-five rabbits were randomly divided into five groups: 1) Saline controls (n=5); 2) Endotoxin-treated alone group (endotoxin 200μg/kg. bw.iv, n=15); 3) Endotoxin combined with BN52021 pretreatment group (PAF receptor antagonist BN52021 with a dose of 5 mg/kg.bw.ip was infused about 10 minutes before endotoxin treatment, n=11); 4) Exogenous PAF-treated alone group (PAF 0.1μg/kg.bw.iv, n=8); 5) PAF combined with BN52021 pretreatment group (n=6).

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