【摘要】 目的 为了解转化生长因子β3(TGF-β3)在病毒性肝炎肝组织中的表达及其与肝纤维化的关系。方法 对33例病毒性肝炎病人肝组织进行了TGF-β3免疫组化研究。结果 TGF-β3主要分布在血窦壁及窦内细胞、坏死灶、汇管区、纤维间隔、假小叶中的肝细胞以及重型肝炎坏死区的肝细胞。其阳性表达的强度为肝硬变慢性重型肝炎>慢性肝炎重度>中度>轻度>急性肝炎；与肝功能损害的关系表明，随着TGF-β3在肝组织中表达的增高，血清总胆红质升高明显，而凝血酶原时间活动度明显下降。结论 TGF-β3在肝组织中的表达与病毒性肝类肝纤维化及肝硬变、重型肝炎的发生发展及预后有密切关系。

Abstract 33 specimens of liver biopsy from patients with different types of viral hepatitis were detected for transforming growth factor-β3(TGF-β3) by immunohistochemistry. The results showed that TGF-β3 mainly distributed in the sinusal walls cells in sinus portal. areas fibrous. septum. hepatocytes in pseudolobes and necrotic areas of severe hepatitis. The expressing intensity of TGF-β3, was stronger in the cirrhosis,chronic severe hepatitis than that in the chronic and acute hepatitis. As the expression of TGF-β3 increased,the level of serum billirubin ascended and plasmozyme activity was prolonged.It may be concludcd that the expression of TGF-β3 is correlated with severe hepatitis and the progress of the liver cirrhosis.

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