【摘要】 目的 探讨老年人年龄增长对24小时胃内pH节律的影响。 方法 应用便携式pH测定仪对51例无症状老年人、12例老年十二指肠球部溃疡患者进行24小时pH测定，并与29例无症状非老年人、20例非老年十二指肠球部溃疡患者对照分析。 结果 45例(88.4%)无症状老年人其24小时中位pH值与非老年人大体相同。老年人与非老年人比较，中位pH值分别为1.82、1.44，基线pH值分别为1.09、1.21，两组间虽略有不同，但差异无显著性(均为P>0.05)。峰值pH值老年人明显高于非老年人(4.36及3.14，P<0.05)。老年无症状者与老年十二指肠球部溃疡患者、非老年无症状者与非老年十二指肠球部溃疡患者比较，夜间中位pH值差异均有显著性(分别为2.15与1.17及1.95与1.06，均为P<0.05)。 结论 本实验证实，年龄增长并不影响空腹状态下的胃内氢离子活性。

【Abstract】 Objective To study theinfluence of age on 24-h intragastric pH rhythm. Methods Circadianpattern of intragastric pH in 51 elderly asymptomatic subjects and 12 elderly patientswith duodenal ulcer (DU) was studied by using 24 hour pH monitoring. Results Comparedwith 29 non-elderly asymptomatic subjects, 45 elderly subjects (88.4%) had similar levelof 24-h median pH. There was no significant difference in the level of 24-h median pH(1.82 vs 1.44), baseline pH (1.09 vs 1.21) between the elderly and non-elderly groups. Butthe value of post-prandial plateau pH was higher in the elderly group than that innon-elderly group (4.36 vs 3.14, P<0.05). The value of median pH at night in elderlypatients with DU was lower than that in asymptomatic elderly subjects (2.15 vs 1.17, P<0.05).Conclusions It is suggested that the factor of age does notinfluence the activity of intragastric hydrogen ion.

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