【摘要】 目的 探索胆石病家族聚集性及遗传方式。方法 采用遗传流行病学病例对照研究方法，对317个家系(138个胆石病先证家系和179个对照家系)进行研究。结果 病例组一级亲属总的胆石病患病率为2.60%，显著高于对照组的1.29%(χ² ＝4.78，P＝0.0288)；分离比为显著低于0.25，不符合单基因遗传疾病的特征；遗传度估算显示，该病一级亲属中，遗传度为21.80%，其中男性亲属的遗传度为36.34%，显著高于女性亲属的14.15%。结论 在胆石病的病因中，遗传因素起一定作用，尤其对男性作用更为明显。

    

A study on the geneticepidemiology of gallstone disease

YANG Song,TAN Yongfei,YURongbin,et al.

Yixin People's Hospital of JiangsuProvince,Yixin 214200

【 Abstract】 Objective To explore the genetic model of gallstone disease (GD). Methods A case-control studyincluding 317 pedigrees (138 cases and 179 controls) was conducted. Results The prevelence of thefirst-degree relatives in cases was 2.60%, significantly higher than that noticed incontrols (1.29%). Segregation analysis showed that GD did not possess the characteristicsof monogenic model. Meanwhile the results showed that the heritability of the first-degreerelatives was 21.80%,with male 36.34% which was significantly higher than the females(14.15%). Conclusion This study indicated that the genetic factors played an important role in the occurrence of GD, especially in males.

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