摘要 目的 探讨老年大鼠肝脏枯否细胞的前体细胞即外周血单核细胞对内毒素的反应性。方法 将不同浓度脂多糖(内毒素)加入经培养的6及24月龄大鼠单核细胞中，2小时后检测单核细胞细胞骨架中肌动蛋白、肌球蛋白、波形蛋白等成分的含量。 结果 老年大鼠单核细胞骨架成分的含量显著低于年轻大鼠(P<0.01)。低浓度脂多糖使单核细胞骨架成分的含量增加，以年轻大鼠更为显著(P<0.01)；高浓度脂多糖使单核细胞骨架成分的含量减少，以老年大鼠更显著(P<0.01)。 结论 老年大鼠单核细胞细胞骨架老化明显，更易受内毒素的损伤。

The influence of lipopolysaccharide of various concentrations on cytoskeleton components ofmonocytes in aged rats Wang Huaizhi, Han Benli, Sun Wenbing, et al. Hepatobiliary Surgery Center,Southwest Hospital, the Third Military Medical College, Chongqing 400038

Abstract Objective To evaluate the reactivity of monocytes, the precursors ofKuffer's cells, toendotoxin lipopolysaccharide inaged rats. Methods Lipopolysaccharideof various concentrations was added into the suspension of monocytes, and the contents of actin, myosin and vimentin in the cytoskeleton were measured two hours later. Results Cytoskeleton contents of aged rats were distinctly lower than those of young rats (P< 0.01).Lipopolysaccharide of low concentration led to increase cytoskeleton contents ......