 |
关键词：
【摘要 】 目的 研究血脂康对高胆固醇血症患者的调脂作用并与辛伐他汀比较。方法 28例高胆固醇血症患者随机分为两组，服药前及服药后4、8周测定血脂。结果 (1)服药后4周TC分别降低了20.7%和22.5%(P值均<0.001)；血脂康降低血清低密度脂蛋白胆固醇(LDL-C)作用与辛伐他汀相似，LDL-C水平分别降低了28.2%和33%(P值均<0.01)；(2)血脂康明显降低17.4%的血清TG水平(P<0.05)；(3)服血脂康和辛伐他汀4周后，载脂蛋白(Apo)A1却分别增加了12.7%和13.6%(P值均<0.01)；ApoB水平均下降了8%左右(P<0.05)；分别使脂蛋白(a)[Lp(a)]水平降低了31.3%(P<0.01)和27.8%(P<0.05)；(4)除了治疗8周后Lp(a)水平进一步下降外，两种药物治疗8周后的调脂作用与4周比较无明显差异。结论 血脂康能显著降低Ⅱa和Ⅱb型高胆固醇血症患者血清TC和LDL-C，其作用与辛伐他汀相等；血脂康降低TG作用优于辛伐他汀。
Comparison of the effects of Xuezhikang with simvastatin on lipid profile modification in patients with hypercholestrolemia Lu Guoping* , Huo Shuqin, Shen Yongchu, et al. * The Affiliated Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025
【 Abstract 】 Objective To study the effects of Xuezhikang on lipid profile modification in patients with hypercholesterolemia and to compare it with simvastatin. Methods 28 patients with hypercholesterolemia were randomly divided into a treatment group (n=15, Xuezhikang 1.2 g/d qn, P.O) and a control group (n=13, simvastation 10 mg/d qn, P.O). Blood samples were taken from forearm vein (fasting for 12h) before and 4 weeks, 8 weeks after the treatment. Serum lipid profile was determined enzymatically and turbimetrically. Results (1) The effects of Xuezhikang in lowering serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels were the same as simvastatin; the concentrations of TC and LDL-C decreased by 20.7% and 18.2% in the Xuezhikang group (P<0.001, <0.01) and by 22.5% and 33.0% in the control group (P<0.001, <0.01) respectively. (2) Xuezhikang decreased serum triglyceride (TG) levels by 17.4% (P<0.05) after 4 weeks of treatment, but the effect of simvastatin lowering TG was not statistically significant. (3) Although concentrations of high density lipoprotein cholesterol (HDL-C) was not changed after 4 weeks of treatment; apolipoprotein A1 (ApoA1) levels elevated by 12.7% and 13.6% in the two groups respectively; apolipoprotein B (Apo B) levels lowered by about 8% (P<0.05) in both groups. It is interesting to note that lipoprotein(a) levels decreased by 31.3% and 27.8% (P<0.05) in both the Xuezhikang and simvastatin groups after 8 weeks of treatment. (4) Difference of the effects of both medicines on serum lipid profile at the end of 4 weeks and 8 weeks were not significant, though further lowering of the concentration of Lp(a) was noted in the Xuezhikang group after 8 weeks as compared with 4 weeks. Conclusion Xuezhikang could markedly decrease TC and LDL-C concentrations in patients with hypercholesterolemia and the effects of Xuezhikang were the same as those of simvastatin. TG lowering effects of Xuezhikang were superior to that of simvastatin.
【 Key words 】 Hypercholesterolemia Simvastatin Xuezhikang
高胆固醇血症的治疗在冠心病的一、二级预防中起重要作用[1～3] ......
您现在查看是摘要页，全文长 14852 字符。