【摘要】 目的 探讨颧部褐青色痣的发病危险因素。方法 对100例患者进行1∶1配对的病例对照研究，通过条件logistic回归多因素和单因素分析筛选主要危险因素。结果 该病患者有较高的家族史暴露率，提示该病有“遗传易感性”存在。环境危险因素有化妆品应用史和紫外线暴露史，但每一因素均不能解释所有病例。结论 认为遗传易感性与环境危险因素的联合作用可以解释颧部褐青色痣的发病过程，遗传基因的定位与环境因素的联合研究对揭示颧部褐青色痣的病因具有重要意义。

    

A case-control study on the risk factors in naevus fusco-caeruleus zygomaticus WANG Zhizhong^* ,WEI Liankun,MU Xianlong,et al. *Departmentof Dermatology, Changhai Hospital,the Second Military Medical Univer sity, Shanghai 200433

    【Abstract】 Objective To determine the risk factors ofnaevus fusco-caeruleus zygomaticus, a case-control study was conducted in 100 ca ses. Methods Theselection of major risk factors was thro ugh logistic regression and χ² -test. Results Itwas su ggested that the high exposed rate in the family history of objectives was relat edto “genetic susceptibility”. Histories of using cosmetics and exposure to u ltravioletray were identified as enviromental risk factors. However,there was no single factor thatcould completely explain the etiology of naevus fusco-cae ruleus zygomaticus. Conclusion Webelieve that coordinati ng effects of both susceptibility in genetics and enviromentalrisk factors may play important roles in the pathogenesis of naevus fusco-caeruleus zygomaticus. Thus combined research on the location of gene mutation with enviromentalfactor s is important in the discovery of the etiology of naevus fusco-caeruleus zygomaticus.

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