郎振为 郭兴会 孟忻 张士杰 李伯光 魏民 100054 北京佑安医院(郎振为、郭兴会、孟忻、张士杰)；北京中医药大学(李伯光、魏民) 中华内科杂志 1998 0 37 5


    关键词： 期刊 zhnkzz 0 肾小球肾炎肝炎病毒组，丙型免疫组织化学 fur -->


    

【摘要 】 目的 探讨丙型肝炎病毒(HCV)感染与肾小球肾炎病变的关系。方法 应用免疫组化技术以丙型肝炎病毒抗体(抗-HCV)NS3和抗-HCV NS5单克隆抗体对21例丙型肝炎患者尸检石蜡包埋肾组织中的丙型肝炎抗原(HCAg)进行检测。结果 HCAg的检出率为61.9%(13/21)，其中膜增殖性肾炎(MPGN)11例，系膜增殖性肾炎(MsPGN)1例，1例未见明显病变。HCAg阳性颗粒定位于肾小球系膜区、系膜细胞及肾小管上皮细胞胞浆内。21例中有17例血清乙型肝炎病毒(HBV)标志呈阳性，同单纯HBV感染组相比，本组患者出现肾小球肾炎病变更为多见(χ² =8.5，P<0.01)。结论 MPGN型是HCV感染后肾小球肾炎病变的主要类型。

Hepatitis C virus-induced glomerulonephritis Lang Zhenwei^* , Guo Xinghui, Meng Xing, et al. ^* Beijing Youan Hospital, Beijing 100054

     【 Abstract 】 Objective To investigate the existence of hepatitis C antigen (HCAg) and its relationship with glomerulonephritis in renal tissue. Methods Hepatitis C virus NS3 (HCV NS3) and hepatitis C virus NS5 (HCV NS5) were detected with immunohistochemical method in the paraffin-embedded renal tissue taken from 21 autopsied cases with HCV infection. Results Among the 21 cases, 13(61.9%) had HCV NS3 or HCV NS5 in their renal tissue. HCAg were localized in the mesangial matrix and in the cytoplasm of glomerular mesangial or tubular cells. Pathological changes were found in 12 of the 13 positive cases, 11 were identified as membranoproliferative glomerulonephritis (MPGN) and 1 as mesangial proliferative glomerulonephritis (MsPGN). 17 patients were serologically superinfected with hepatitis B virus (HBV), but it seemed that the renal lesion in this group was more common than in the patients with HBV infection alone ( χ ² =8.5, P<0.01). Conclusion MPGN is the major type of glomerulonephritis associated with HCV infection.

     【 Key words 】 Glomerulonephritis Hepatitis C viruses Immunohistochemistry

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