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【摘要】 目的 观察替硝唑对阿米巴肝脓肿的临床疗效。方法 以每日顿服替硝唑 2.0 g，5日疗法治疗33例阿米巴肝脓肿患者，并与甲硝唑14日疗法治疗31例阿米巴肝脓肿患者进行比较。结果 替硝唑组患者体温恢复正常时间(3.7±0.5天)，平均住院天数(24.3±1.5天)及总有效率(78.8%)与甲硝唑组比较，差异无显著性(P>0.05)。但替硝唑组患者脓腔缩小所需时间较短，肝区疼痛消失较早，不良反应亦比甲硝唑组较少(P<0.05)。结论 替硝唑是一种治疗阿米巴肝脓肿的新的良好药物。
Efficacy of tinidazole in treating 33 cases of amebic liver abscess Xie Yunqiu* , Xu Zhibiao, Guo Zengzhu, et al. * People's Hospital of Leiyang City, Hunan Province, Leiyang 421800
【Abstract 】 Objective To study the therapeutic efficacy and side reactions of tinidazole and metronidazole in the treatmant of amebic liver abscess. Methods Two comparable groups of 33 and 31 cases were used. Results The effective rate in the tinidazole group was 78.8% with a single daily dose of 2.0 g for 5 successive days, and in the metronidazole group 71.0%, with a dose of 1 ～1.2 g daily for 14 days. There was no significant difference in the effective rate, fever clearance time, and average hospitalization days in both groups. However, the reduction in size of abscess cavities and the relief of pain in hepatic region were much more rapid and earlier with lesser side effects in the tinidazole group than in the metronidazole group (P<0.05). Conclusion Both tinidazole and metronidazole are effective in the treatmant of hepatic amoebiasis, but tinidazole may be considered as the drug for first choice due to its short therapeutic course and less side effects.
【Key words 】 Liver abscess, amebic Tinidazole Metronidazole
替硝唑 (tinidazole) 是60年代后期研制的一类硝基咪唑类衍生物 ......
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