陈华德 赖文 谢举临 郑少逸 高辉 郑利志 陈华德 赖文 郑少逸 高辉 郑利志 广州，广东省人民医院烧伤科 510080；谢举临 中山医科大学附属第一医院烧伤科 中华整形烧伤外科杂志 1999 0 15 3


    关键词：生长激素；烧伤；创面愈合 期刊 zhzxsswkzz 0 论 著 fur -->


    

【摘要】 目的 探讨生长激素对大面积烧伤病人蛋白质代谢、创面愈合能力、免疫功能及预后的作用。方法 选择42例大面积烧伤病人，随机分为重组人生长激素(rhGH)治疗组和对照组，并分析比较两组一般状况、蛋白质代谢、创面愈合时间、免疫功能。结果 rhGH组一般情况良好，体重增加，血浆蛋白质水平、供皮区愈合时间及体液和细胞免疫功能均比对照组好。结论 rhGH能有效促进蛋白质合成，缩短创面愈合时间，增强机体免疫能力，从而提高大面积烧伤病人生存率。

The study of growthhormone on wound healing rate in adult burns

CHEN Huade^* , LAI Wen,XIE Julin,et al.^* Guangdong Provincial People's Hospital,Guangzhou 510080

【 Abstract 】 Objective To determine the effects of rhGH on wound healing in adultburn patients.Methods 42 patients with burn wounds covering over 83% of total bodysurface area were enrolled in this placebo controlled prospective study.They werecomparable in nutrient intake,TBSA,and full thickness burn area.For rhGH group patientsrhGH subcutaneously was given in the dose of 0.2U*kg^-1 at 8 a.m. each morningfor 14 days.The control group patients were given normal saline as placebo.Proteincatabolism,immuncompetence,healing time of burn wounds and donor sites were assayed.Results ① The patients in rhGH grouphad higher serum levels in albumin,transferrin,prealbumin and CD₄ T-cells(P<0.01). ② Thehealing time of autologous skin grafting and donor site and the length of hospital staywere significantly shorter in rhGH group patients compared with control group.Conclusion rhGH could enhance the woundhealing rate,improve protein anabolism and reduce the length of hospital stay in severeburn patients.

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