王贵强 景奉国 苏树祥 黄桂馨 张东 张东普 侯永建 北京燕山石油化工公司职工医院烧伤整形科 102500 中华整形烧伤外科杂志 1999 0 15 4


    关键词：间甲酚；化学烧伤；损伤；治疗 期刊 zhzxsswkzz 0 论著 fur -->


    

【摘要】 目的 开展间甲酚化学烧伤动物实验研究，为临床治疗提供理论依据。方法 将间甲酚原液涂在家兔背部，并随机分为对照、手术切痂、SD-Ag涂药、饱和硫酸钠湿敷及自来水冲洗组。检测血液中BUN、ALT、AST、GGT、AKP 5种生化指标。观察心、肝、脑、肺、肾的病理变化及超微结构变化。结果 间甲酚不仅可对皮肤造成深度烧伤，而且经过皮肤渗透还可引起全身主要脏器的损害。结果显示：血液中5种生化指标均出现异常，光镜和电镜观察组织细胞均有异常变化。结论 4种不同治疗方法均有效，其中以手术切痂、外涂SD-Ag最好，饱和硫酸钠湿敷次之，用自来水冲洗可减轻间甲酚对皮肤的直接损伤。由于间甲酚对内脏器官影响较大时间较长，因此在治疗烧伤创面的同时，应用保护心脏、肝脏、肾脏药物的时间也要适当延长。

An experimental study of metacresol burn

WANG Guiqiang, JING Fengguo, SU Shuxiang, et al. Hospital of Beijing Yanshan Petrochemical Corporation,Beijing 102500

【 Abstract 】 Objective To study the characteristics of metacresol burn.Methods Metacresol of 99.6% was used.The animals were randomly seperated into control group,excision group,topical SD-Ag group,saturated sodium sulfate wet compress group,and warm running water flushing group.Results It was proved that metacresol could not only cause deep burns to skin but also penetrate skin and to produce impairment of functions of the main internal organs of the body,as shown by abnormalities in blood BUN,GPT,GOT,GGT,and AKP.Pathological changes were also found in the liver,heart,brain,kidney,and skin with light and electron microscopy.Conclusion Through comparison of the four different treatment methods for metacresol burns,it is concluded that excision of the wound followed by skin grafting should be done as early as possible to minimize absorption of the chemical.Topical application of SD-Ag or sodium sulfate wet compress,and flushing with running water can alleviate direct injury to skin.Drugs to protect the heart,liver,and kidney should be used for a longer period than usual.

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