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Ⅱ度烧伤病人皮肤角朊细胞ICAM-1的表达
http://www.100md.com 《中华整形烧伤外科杂志》 1999年第1期
烧伤|角朊细胞|细胞间粘附分子-1|创面愈合,关键词:
Ⅱ度烧伤病人皮肤角朊细胞ICAM-1的表达

     朱雄翔 李永林 董茂龙 陈璧 汤朝武 王剑波 (朱雄翔、李永林、董茂龙、陈璧、汤朝武)710032 西安,第四军医大学西京医院烧伤科,(王剑波)病理科 中华整形烧伤外科杂志 1999 0 15 1


    关键词:烧伤;角朊细胞;细胞间粘附分子-1;创面愈合 期刊 zhzxsswkzz 0 论 著 fur -->


    



    【摘要】 目的 探讨Ⅱ度烧伤创面愈合过程中角朊细胞间粘附分子-1(ICAM-1)的表达及其意义。方法 应用免疫组织化学染色技术,对烧伤后不同时间Ⅱ度烧伤皮肤组织角朊细胞ICAM-1的表达进行动态观察。8例健康人皮肤,6例烧伤病人正常皮肤及8例Ⅱ度烧伤愈合后增生性瘢痕组织为对照组。结果 健康人正常皮肤基底层细胞ICAM-1可低表达,烧伤病人正常皮肤基底层细胞ICAM-1可表达增强。Ⅱ度创面基底层细胞伤后1周内ICAM-1表达轻度增高,2周内明显增强,2~4周稳定高表达,ICAM-1呈极性分布,新生上皮多层角朊细胞ICAM-1表达显著增强,ICAM-1阳性细胞呈长柱状排列。结论 Ⅱ度烧伤皮肤角朊细胞ICAM-1表达增强可能与创基炎性细胞浸润相关,具有诱导角朊细胞增殖、迁移,加速上皮化的作用。

    The expression of ICAM-1on the keratinocytes in second degree human burn skin

ZHU Xiongxiang,LI Yonglin,DONGMaolong,et al.

    Burn Unit,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032

Abstract Objective Toinvestigate the significance of changes in intercellular adhesion molecule-1 (ICAM-1)expression on keratinocytes(KCs) during wound healing of second degree burn.Methods With immunohistochemistry technique,the ICAM-1 expression in second degree burnwounds in patients were investigated at four different postburn periods.The normal skinsfrom 6 burn patients (BNG),the normal skins from 8 healthy volunteers (HVG) and the scartissues (SG) from 8 patients served as controls.Results There was poorexpression of ICAM-1 on basal cells in normal skins of healthy volunteers,while theexpression of ICAM-1 enhanced in normal skins of burn patients.On basal cells in seconddegree burn wounds,the expression of ICAM-1 slightly increased in the first weekpostburn,obviously enhanced in the second week,and in the third or fourth week,theexpression continued to keep strong.In addition,the ICAM-1 in KCs showed polardistribution,and the expression of ICAM-1 markedly enhanced on the multilayer KCs inneogenetic epithlium and the positive cells arranged columnarly.Conclusion Theenhanced expression of ICAM-1 on KCs in second degree burn wounds might be related toinvasion of inflammatory cells beneath wound.It might play a role in inducingproliferation and migration of KCs and accelerating epithelization.

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