关键词:烧伤;角朊细胞;细胞间粘附分子-1;创面愈合
【摘要】 目的 探讨Ⅱ度烧伤创面愈合过程中角朊细胞间粘附分子-1(ICAM-1)的表达及其意义。方法 应用免疫组织化学染色技术,对烧伤后不同时间Ⅱ度烧伤皮肤组织角朊细胞ICAM-1的表达进行动态观察。8例健康人皮肤,6例烧伤病人正常皮肤及8例Ⅱ度烧伤愈合后增生性瘢痕组织为对照组。结果 健康人正常皮肤基底层细胞ICAM-1可低表达,烧伤病人正常皮肤基底层细胞ICAM-1可表达增强。Ⅱ度创面基底层细胞伤后1周内ICAM-1表达轻度增高,2周内明显增强,2~4周稳定高表达,ICAM-1呈极性分布,新生上皮多层角朊细胞ICAM-1表达显著增强,ICAM-1阳性细胞呈长柱状排列。结论 Ⅱ度烧伤皮肤角朊细胞ICAM-1表达增强可能与创基炎性细胞浸润相关,具有诱导角朊细胞增殖、迁移,加速上皮化的作用。
The expression of ICAM-1on the keratinocytes in second degree human burn skin
ZHU Xiongxiang,LI Yonglin,DONGMaolong,et al.
Burn Unit,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032
【 Abstract 】 Objective Toinvestigate the significance of changes in intercellular adhesion molecule-1 (ICAM-1)expression on keratinocytes(KCs) during wound healing of second degree burn.Methods With immunohistochemistry technique,the ICAM-1 expression in second degree burnwounds in patients were investigated at four different postburn periods.The normal skinsfrom 6 burn patients (BNG),the normal skins from 8 healthy volunteers (HVG) and the scartissues (SG) from 8 patients served as controls.Results There was poorexpression of ICAM-1 on basal cells in normal skins of healthy volunteers,while theexpression of ICAM-1 enhanced in normal skins of burn patients.On basal cells in seconddegree burn wounds,the expression of ICAM-1 slightly increased in the first weekpostburn,obviously enhanced in the second week,and in the third or fourth week,theexpression continued to keep strong.In addition,the ICAM-1 in KCs showed polardistribution,and the expression of ICAM-1 markedly enhanced on the multilayer KCs inneogenetic epithlium and the positive cells arranged columnarly.Conclusion Theenhanced expression of ICAM-1 on KCs in second degree burn wounds might be related toinvasion of inflammatory cells beneath wound.It might play a role in inducingproliferation and migration of KCs and accelerating epithelization.
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