李建兵 郝新光 梁杰 524001 湛江，广东医学院整形外科研究所(李建兵现在杭州市整形医院 310014) 中华整形烧伤外科杂志 1999 0 15 1


    关键词：组织扩张术；自由基；SOD；MDA 期刊 zhzxsswkzz 0 论 著 fur -->


    

【摘要】 目的 探讨组织扩张过程中自由基的生成及其对组织扩张的影响。方法 SD大白鼠背部置入20ml圆形扩张器，常规扩张23～25天，于最后一次扩张前、扩张后1，6，12和24h分别测定扩张皮肤组织中SOD活性和MDA含量；同时观察自由基清除剂SOD对扩张面积、长度的影响。结果 SOD活性和MDA含量扩张后1，6及12h与扩张前比较差异有非常显著意义，至扩张后24 h基本回复到扩张前水平；SOD治疗组扩张面积、长度与NS对照组差异有显著意义，以6～24天为最明显。结论 组织扩张过程中生成自由基，SOD能增加扩张面积、长度，为安全、快速及有效地皮肤软组织扩张提供新的思路。

    Preliminary experimentalstudy on free radicals in expanded soft tissue

LI Jianbing,HAO Xinguang,LIANGJie.

    Department of Plastic Surgery,Guangdong Medical College,Zhanjiang 524001

【 Abstract 】 Objective To inquire into the formation of freeradicals during tissue expansion and its influence on tissue expansion.Method Expanders of 20 ml were placed beneath the dorsal skin of SD rats,and the conventionalexpansion course took about 23 to 25 days.The activity of SOD and the content of MDA inskin were determined prior to the last expansion,1h,6h,12h and 24h after the lastexpansion,respectively.Meanwhile,the effect of SOD on expansion area and length wasobserved.Result The activity of SOD and the content of MDA at 1h,6h,and12h after expansion were significantly different from those before expansion,while theactivity of SOD and the content of MDA at 24h after expansion were almost the same asthose before expansion.The difference of expansion area and length between SOD and NSgroups was significant,expecially during 16 to 24 days.Conclusion Tissueexpansion produces free radicals and SOD can increase expansion area and length.The studyprovides a clue to find a way for safe,rapid and effective soft tissue expansion.

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