孙永华 周业平 蒋朱明 苏虹 闫汝蕴 陈忠 崔世日 100035 北京积水潭医院烧伤科(孙永华、周业平、苏虹、闫汝蕴、陈忠、崔世日)；北京协和医院外科(蒋朱明) 中华整形烧伤外科杂志 1998 0 0 4


    关键词：烧伤；重组人生长激素；氨基酸谱；皮肤移植； 期刊 zhzxsswkzz 0 论著 fur -->


    

【摘要】 目的 探讨生长激素对成人烧伤创面愈合、感染的发病率，住院日以及预后的作用。方法 选择1996年2月至1997年6月间，16例烧伤面积大于50%，Ⅲ度面积大于40%的重度烧伤患者，并随机分为重组人生长激素组(rHGHgroup)和对照组(control group)，伤后当天及20天取外周血进行氨基酸谱分析，记录植皮区和供皮区创面愈合时间以及住院时间，计算伤后第30天全身创面愈合率。结果 rHGH组精神状态和食欲较好，血浆氨基酸谱分析，术后抗生素应用剂量及时间，植皮区和供皮区愈合时间，住院日等rHGH组均优于对照组。结论 伤后早期开始使用rHGH有助于改善全身状况，促进创面愈合，减少并发症。

    The effect of growth hormone on wound healing rate inadult burns Sun Yonghua*,Zhou Yeping,Jiang Zhuming,et al.\+*Department ofBurn,Beijing Burn Institute,Beijing Jishuitan Hospital,100035

    【Abstract】 Objective To determine the wound healing effect of rHGH inadult burn patients.Methods 16 patients with burn wounds covering over60% of total body surface (TBSA) were enrolled in this pacebo controlled prospectivestudy.They were comparable in nutrient intake,TBSA,and full thickness burn area.rHGH grouppatients werer given rHGH subcutaneously in the dose of 0.3u.Kg^-1 at 8 am eachmorning for 10 days beginning from POD 1.The control group patients were given normalsaline as placebo.All the patients received escar excision within 4 days postburn,and theexcision wounds were covered with autologous skin pulp grafting.Serum amino acid profilewas analyzed at day 1 and day 20 post burn.Healing time of burn wound area and donor sitewas recorded.Wound healing rate was assessed at day 30 after day.Results ①The healing time of autologous skin pulp grafting and donorsite,and the length of hospital stay were significantly shorter in GH group patients thancontrol group.②The amino acid profile showed nodifference between two groups at day 1 and was significantly better in GH group at day 20.Conclusion rHGH could enhance the wound healing rate,improve amino acid profile,and reducethe length of hospital stay of severe burn patients.

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