【摘要】 目的 探索HLA-DRB1、DQB1等位基因多态性与系统性红斑狼疮(SLE)的易感性关系。方法 用聚合酶链反应-序列特异性引物(PCR-SSP)方法，对104例健康人和32例SLE患者的HLA-DRB1、DRB3、DRB4、DQB1等位基因进行研究。结果和结论 SLE患者中基因频率升高的有HLA-DRB1*15(P<0.05，RR=2.3)，HLA-DRB1*16(P<0.05，RR=4.86)，而DRB1*04明显低于对照组；未发现DQB1*04等位基因。

    

    Study on HLA-DRB1,DQB1 Allele Susceptibility to Systemic Lup-us Erythematosus Jin Ye,Li Zhexian,Zhang Zhixin,et al.Department of Clinical Laboratory,Beijing FriendshipHospital,Beijing 100050

    【Abstract 】 Objective To explore the allelic polymorphism of HLA-DRB1,DQB1 lociand susceptibility to systemic lupus erythematosus(SLE). Methods Polymerase chain reaction-sequence specific primers(PCR-SSP) were used to study HLA-DRB1, DRB3, DRB4 and, DQB1, alleles in 32 patients with SLE and 104 healthy controls. Results and Conclusion The results showed that the frequencies of DRB1*15(P<0.05,RR=2.3) and DRB1*16(P<0.05,

     ......